Hh Signaling Pathway Antagonist
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Catalog number
1659-1
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Price
Please ask
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Size
1 mg
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Alternative_name
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N’-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl-urea
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Description
Cell-permeable. A potent antagonist of the Hedgehog (Hh) signaling pathway (IC₅₀ = 70 nM).
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CAS Number
330796-24-2
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₃H₁₅ClF₄N₄O₂
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Molecular Weight
490.84
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Cell Permeable
Yes
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Purity
≥97% by HPLC
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Solubilities
DMSO
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Handling
Protect from air and light
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Tag Line
A hedgehog (Hh) signaling pathway inhibitor
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Storage Condition
+4°C
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Shipping Condition
RT
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Shelf Life
24 months
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PubChem CID
9913498
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SMILES
C1=CC=C2C(=C1)C(=O)N(C(=N2)CNC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)C4=CC=C(C=C4)F
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InChi
InChI=1S/C23H15ClF4N4O2/c24-18-10-7-14(11-17(18)23(26, 27)28)30-22(34)29-12-20-31-19-4-2-1-3-16(19)21(33)32(20)15-8-5-13(25)6- 9-15/h1-11H,12H2,(H2,29,30,34)
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InChi Key
NYOXUHUPXGFHIB-UHFFFAOYSA-N
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MSDS Available
Yes
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Additional description
The antagonist receptor ligand binding will be in contrast with agonist activity. Biovision produces more antagonist and receptor related products as 1. Cell nucleus signaling proteins and molecules are part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated effectively and, theoretically, artificial tissues may be created.
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