Inauhzin
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Catalog number9555-25
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Price:
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Size25 mg
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Alternative_name2-((5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-1-(10H-phenothiazin-10-yl)butan-1-one
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DescriptionInauhzin is a potent SIRT inhibitor that effectively reactivates p53 by inhibiting SIRT1 activity. Inauhzin inhibits cell proliferation, induces senescence, and p53-dependent apoptosis of human cancer cells without apparent toxicity to normal cells.
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CAS Number309271-94-1
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₅H₁₉N₅OS₂
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Molecular Weight469.58
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (~5 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent SIRT inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID5494506
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SMILESCCC(C(=O)N1C2=CC=CC=C2SC3=CC=CC=C31)SC4=NC5=C(C6=CC=CC=C6N5)N=N4
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InChiInChI=1S/C25H19N5OS2/c1-2-19(33-25-27-23-22(28-29-25)15-9-3-4-10-16(15)26-23)24(31)30-17-11-5-7-13-20(17)32-21-14-8-6-12-18(21)30/h3-14,19H,2H2,1H3,(H,26,27,29)
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InChi KeyVHUOXERIKQWIJE-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameInauhzin
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Alternative nameInauhzin
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