Anti-Delta 4 (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-6044R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  Delta 4
• Specificity
  This antibody reacts specifically with Delta 4
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  Cytoplasm
• Antigen Source
  KLH conjugated synthetic peptide derived from human DLL4
• Gene ID
  54567
• Swiss Prot
  Q9NR61
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  hdelta2; Delta-like protein 4; Drosophila Delta homolog 4; Delta4; DLL4; UNQ1895/PRO4341
• Also known as
  Delta 4 Polyclonal Antibody
• Other name
  Anti-Delta 4 Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  Delta  
• Gene symbol
  PLCD4, DLL4, POLD4
• Short name
  Anti-Delta 4
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  Delta 4 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:9062
• Gene
  PLCD4
• Long gene name
  phospholipase C delta 4
• Synonyms gene name
  • phospholipase C, delta 4
• GenBank acession
  • AI366170
• Locus
  2q35
• Discovery year
  2000-05-31
• Entrez gene record
  84812
• Pubmed identfication
  • 10702683
  • 9056492
• Classification
  • C2 domain containing phospholipases
  • EF-hand domain containing
  • Phospholipases
• VEGA ID
  OTTHUMG00000154743

Gene info

• Identity
  HGNC:2910
• Gene
  DLL4
• Long gene name
  delta like canonical Notch ligand 4
• Synonyms gene name
  • delta-like 4 homolog (Drosophila)
  • delta-like 4 (Drosophila)
• GenBank acession
  • AF253468
• Locus
  15q15.1
• Discovery year
  2000-07-31
• Entrez gene record
  54567
• Pubmed identfication
  • 10837024
• VEGA ID
  OTTHUMG00000172511
• Locus Specific Databases
  • LRG_1268

Gene info

• Identity
  HGNC:14106
• Gene
  POLD4
• Long gene name
  DNA polymerase delta 4, accessory subunit
• Synonyms gene name
  • polymerase (DNA-directed), delta 4, accessory subunit
  • polymerase (DNA) delta 4, accessory subunit
• Synonyms
  • p12
  • POLDS
• Synonyms name
  • DNA polymerase delta smallest subunit p12
• GenBank acession
  • AF179890
• Locus
  11q13.2
• Discovery year
  2000-12-04
• Entrez gene record
  57804
• Pubmed identfication
  • 10751307
• RefSeq identity
  • NM_021173
• Classification
  • DNA polymerases
• VEGA ID
  OTTHUMG00000167135

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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