GW-3965 hydrochloride

• Catalog number
  9402-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic Acid hydrochloride
• Description
  GW-3965 hydrochloride is a non-steroidal liver X receptor agonist on hLXRα and hLXRβ. GW3965 has an EC₅₀ = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC₅₀ = 190 nM and 30 nM, respectively. Up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.
• CAS Number
  405911-17-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₃H₃₁ClF₃NO₃.HCl
• Molecular Weight
  618.51
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A non-steroidal liver X receptor agonist on hLXRα and hLXRβ
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  16078973
• PubChem CID Link
• SMILES
  C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4.Cl
• InChi
  InChI=1S/C33H31ClF3NO3.ClH/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26;/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40);1H
• InChi Key
  NMPUWJFHNOUNQU-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GW-3965   hydrochloride  
• Short name
  GW-3965 hydrochloride
• Alternative name
  GW-3965 hydrochloride

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