Formyl Peptide Receptor-Like 2 (human) - Clone 2G3
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Catalog number
T-1234.0200
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Price
Please ask
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Size
200ug
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Synonym
FPRL2
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StorageTemperature
+5 ± 3 °C
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HOST
Mouse
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Clone
2G3
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Format
Affinity purified
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Species Crossreactivity
mouse
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Application
IHC
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Conjugate
NA
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Top Categories
Antibodies
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Keywords
Monoclonal; primary antibody
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Additonal Description
UniProt: Q6L5J4. FPRL2 is a 353 amino acid G protein-coupled receptor. Its particular distribution on macrophage subsets of the lung, intestine and skin suggest an involvement in innate immunity against helminths or in allergic diseases. Fittingly, the receptor has also been identified on eosinophils, but not on neutrophils. The endogenous peptide F2L, an acetylated 21 amino acid peptide derived from heme-binding protein, is a most specific ligand for FPRL2 and causes chemotaxis but not degranulation in human eosinophils., F2L is also chemotactic for plasmacytoid dendritic cells which express FPRL2 and up-regulate this receptor during maturation. Application: IHC (f)
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Description
Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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