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MAPKAPK5 Antibody

MAPKAPK5 Antibody is available 1 time from Bioss primary unconjugated antibodies labs

bs-4137R | MAPKAPK5 Antibody size: 0.1ml | 290.90 USD

Catalog number bs-4137R
Price 290.90 USD
Size 0.1ml
1. Gene info
Identity 6889
Gene MAPKAPK5
Long gene name mitogen-activated protein kinase-activated protein kinase 5
Synonyms
  • PRAK
GenBank acession
  • AF032437
Locus 12q24.12-q24.13
Discovery year 1999-03-26
Entrez gene record 8550
Pubmed identfication
  • 9628874
RefSeq identity
  • NM_139078
Classification
  • Mitogen-activated protein kinase-activated protein kinases
Havana BLAST/BLAT OTTHUMG00000169605
2. Gene info
Identity 24091
Gene MAPKAPK5-AS1
Long gene name MAPKAPK5 antisense RNA 1
Synonyms gene
  • C12orf47
Synonyms gene name
  • chromosome 12 open reading frame 47
  • MAPKAPK5 antisense RNA 1 (non-protein coding)
Synonyms
  • FLJ39616
Locus 12q24.12
Discovery year 2006-01-23
Entrez gene record 51275
Pubmed identfication
  • 12477932
RefSeq identity
  • NR_015404
Havana BLAST/BLAT OTTHUMG00000141273
MeSH Data
Name Blotting, Western
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Product images
    MAPKAPK5 Polyclonal Antibody#.png
Product files
Synonym names MK5; MK-5; PRAK; MAPKAP-K5; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAPK-5; p38-regulated/activated protein kinase; MAPKAPK5
Clonality Polyclonal antibody
Category Primary Antibodies
Also known as MAPKAPK5 PAb
Modification(s) None
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MAPKAPK5
Cross reactivity Human, Mouse, Rat
Swiss Prot Q8IW41
Specificity This is a highly specific antibody against MAPKAPK5.
Immunogen range 100-150/473
Long name MAPKAPK5 Primary Polyclonal Antibody
Subcellular location Cytoplasm, Nucleus
Gene ID number 8550
Tested Applications WB, IHC-P, IF(IHC-P)
Recommended dilutions WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Modification site(s) Unmodified antibody
Background of the target antigen Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
Concentration 1ug per 1ul
Purification method This antibody was purified via Protein A.
Cross reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Target Antigen MAPKAPK5
Storage conditions Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Conjugation Unconjugated
Clone number Polyclonal antibody
Properties If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetMAPKAPK5
Short name MAPKAPK5 Antibody
Technique Antibody
Alternative name MAPKAPK5 (Antibody to)
Alternative technique antibodies
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