MAPKAPK5 Antibody

• Catalog number
  bs-4137R
• Price
  Please ask
• Size
  0.1ml

• Long name
  MAPKAPK5 Primary Polyclonal Antibody
• Also known as
  MAPKAPK5 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  MAPKAPK5
• Specificity
  This is a highly specific antibody against MAPKAPK5.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  100-150/473
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MAPKAPK5
• Gene ID number
  8550
• Swiss Prot
  Q8IW41
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  MK5; MK-5; PRAK; MAPKAP-K5; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAPK-5; p38-regulated/activated protein kinase; MAPKAPK5
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MAPKAPK5  
• Gene symbol
  MAPKAPK5-AS1, MAPKAPK5
• Short name
  Anti-MAPKAPK5
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  MAPKAPK5 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:24091
• Gene
  MAPKAPK5-AS1
• Long gene name
  MAPKAPK5 antisense RNA 1
• Synonyms gene
  • C12orf47
• Synonyms gene name
  • chromosome 12 open reading frame 47
  • MAPKAPK5 antisense RNA 1 (non-protein coding)
• Synonyms
  • FLJ39616
• Locus
  12q24.12
• Discovery year
  2006-01-23
• Entrez gene record
  51275
• Pubmed identfication
  • 12477932
• RefSeq identity
  • NR_015404
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000141273

Gene info

• Identity
  HGNC:6889
• Gene
  MAPKAPK5
• Long gene name
  MAPK activated protein kinase 5
• Synonyms gene name
  • mitogen-activated protein kinase-activated protein kinase 5
• Synonyms
  • PRAK
  • MK5
• GenBank acession
  • AF032437
• Locus
  12q24.12-q24.13
• Discovery year
  1999-03-26
• Entrez gene record
  8550
• Pubmed identfication
  • 9628874
• RefSeq identity
  • NM_139078
• Classification
  • MAPK activated protein kinases
• VEGA ID
  OTTHUMG00000169605

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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