anti-SMAD2 Antibody
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Catalog number49-314
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PricePlease ask
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Size0.05 mg
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Gene infoSMAD2 is an intracellular protein belonging to the Dwarfin (DWA/B)/SMAD family. SMAD2 associates with SMAD4 for translocation to nucleus. It acts as an intracellular mediator of TGFbeta family of cytokines and activin type 1 receptor (ACVR1C). Hence it regulates multiple cellular processes like cell growth, proliferation, differentiation, and apoptosis and also cooperates with transcription factors to regulate expression of defined genes. Apart from playing an important role in TGFbeta1-induced CTGF expression they also act as markers of EMT in human PTECs. It also acts as an integrator of multiple signals in the regulation of NOS3 expression. It is ubiquitously expressed in most of the tissues and is responsible for colorectal, hepatocellular, lung and breast carcinomas as well as cervical cancer.
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Gene namesSMAD2, HMAD-2, HSMAD2, JV18-1, Mad protein homolog smad2, MADR2, MADH2, SMAD 2, MAD homolog 2, Mad-related protein 2, JV18, Mother against DPP homolog 2, Mothers against DPP homolog 2, Sma- and Mad-related protein 2, SMAD family member 2
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Antibodie s labelunlabelled serum
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PurityProtein G Column
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Ab raised inRabbit
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TypePolyclonal
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AntigenSMAD2 antibody was made against amino acids 234 - 249 of SMAD2 (Human).
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Immuno applicationWestern Blot, immuno-histo-chemistry
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Antibody adviceSMAD2 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 ug/mL.
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Suspention pH azidePBS, 0.05% BSA, 0.05% sodium azide
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Keep atSMAD2 antibody can be stored short term 4 grades C. For long term storage aliquot and store at -20 grades C. As with all antibodies avoid freeze/thaw cycles.
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Works withBat, Gibbon, Bovine, Chicken, Dog, Xenopus, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat
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Omim nr13633914
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Ncbi nrQ15796
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Vial with antibodyin solution
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NCBI GENE nr4087
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GENE symbolSMAD2
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Antigene nameSMAD family member 2
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SourceHomo sapiens
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Protein nrQ15796
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolSMAD2
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Short nameanti-SMAD2 Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toSMAD2 (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetSMAD family member 2, hMAD-2 and hSMAD2 and JV18 and JV18-1 and MADH2 and MADR2, SMAD2 and IDBG-3127 and ENSG00000175387 and 4087, transforming growth factor beta receptor, nuclei, Smad2 and IDBG-159056 and ENSMUSG00000024563 and 17126, SMAD2 and IDBG-644642 and ENSBTAG00000039916 and 515125,516010
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Gene info
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Identity
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Gene
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Long gene nameSMAD family member 2
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Synonyms gene
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Synonyms gene name
- MAD, mothers against decapentaplegic homolog 2 (Drosophila)
- SMAD, mothers against DPP homolog 2 (Drosophila)
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Synonyms
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GenBank acession
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Locus
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Discovery year1996-11-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- SMAD family
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
