BAR-502
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Catalog numberB1965-5
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PricePlease ask
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Size5 mg
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Alternative_name(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-4-hydroxybutan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol; BAR502
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DescriptionBAR-502 is a dual FXR (farnesoid X receptor) and GPBAR1 (G protein-coupled bile acid-activated receptor) agonist. BAR-502 promotes browning of white adipose tissue and reverses liver steatosis and fibrosis. BAR502 protects against liver damage caused by HFD by promoting the browning of adipose tissue.
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CAS Number1612191-86-2
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₅H₄₄O₃
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Molecular Weight392.62
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA dual FXR (farnesoid X receptor) and GPBAR1 (G protein-coupled bile acid-activated receptor) agonist
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID129317950
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SMILESCCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCO)C)C)O
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InChiInChI=1S/C25H44O3/c1-5-17-21-14-16(27)8-11-25(21,4)20-9-12-24(3)18(15(2)10-13-26)6-7-19(24)22(20)23(17)28/h15-23,26-28H,5-14H2,1-4H3/t15?,16?,17?,18-,19+,20-,21+,22+,23?,24-,25-/m1/s1
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InChi KeyHYCMOIGNYNCMRH-BNVZFTBUSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolBFAR, ADRB2, MIR502, AP1AR, GPBAR1
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Short nameBAR-502
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Alternative nameBAR-502
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Gene info
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Identity
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Gene
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Long gene namebifunctional apoptosis regulator
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-05-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Sterile alpha motif domain containing
- Ring finger proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameadrenoceptor beta 2
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Synonyms gene
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Synonyms gene name
- adrenergic, beta-2-, receptor, surface
- adrenoceptor beta 2, surface
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Synonyms
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GenBank acession
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Locus
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Discovery year1990-09-10
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Entrez gene record
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RefSeq identity
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Classification
- Adrenoceptors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 502
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Synonyms gene
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Synonyms
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Locus
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Discovery year2005-07-15
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR500 family
Gene info
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Identity
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Gene
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Long gene nameadaptor related protein complex 1 associated regulatory protein
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Synonyms gene
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Synonyms gene name
- chromosome 4 open reading frame 16
- adaptor-related protein complex 1 associated regulatory protein
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-09-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameG protein-coupled bile acid receptor 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-01-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- G protein-coupled bile acid receptor
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VEGA ID