CD195 (CC-Chemokine Receptor 5) Mouse Monoclonal Antibody

• Catalog number
  MBS439043
• Price
  Please ask
• Size
  5x0.1 mg (With BSA & Azide at 0.2mg/mL)

• Products_type
  Antibody
• Products_short_name
  [CD195]
• Products_name_syn
  [CC Chemokine Receptor Type 5; CC-CKR-5; CCCKR5; CCR5; Chemokine CC motif receptor 5; Chemokine receptor CCR5; CHEMR13; CKR5; CMKBR5; HIV-1 fusion coreceptor; IDDM22; MIP-1 alpha receptor]
• Other_names
  [C-C chemokine receptor type 5; C-C chemokine receptor type 5; C-C chemokine receptor type 5; C-C motif chemokine receptor 5 (gene/pseudogene); CHEMR13; HIV-1 fusion coreceptor; CD_antigen: CD195]
• Products_gene_name
  [CCR5]
• Other_gene_names
  [CCR5; CCR5; CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; CMKBR5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5]
• Clonality
  Monoclonal
• Clone
  [12D1]
• Reactivity
  Human
• Specificity
  Reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Tested_application
  Flow Cytometry (FC/FACS), Immunofluorescence (IF)
• Properties
  If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Description
  Chemokines, chemokine receptors, ligands , motif chemokines and cytokines are supplied by MyBioSource in 1. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• French translation
  anticorps

• Gene target
  CD195   CC-Chemokine   Receptor   Monoclonal  
• Gene symbol
  CCR5, CCR3, CCR4, CCR2
• Short name
  CD195 (CC-Chemokine Receptor 5) Mouse Monoclonal Antibody
• Technique
  Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
• Host
  Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
• Isotype
  IgG2a, kappa
• Species
  Mouse, Mouses
• Alternative name
  CD195 (CC-Chemokine Receptor 5) Mouse monoclonal (antibody to-)
• Alternative technique
  antibodies, murine

Gene info

• Identity
  HGNC:1606
• Gene
  CCR5
• Long gene name
  C-C motif chemokine receptor 5
• Synonyms gene
  • CMKBR5
• Synonyms gene name
  • chemokine (C-C motif) receptor 5
  • chemokine (C-C motif) receptor 5 (gene/pseudogene)
  • C-C motif chemokine receptor 5 (gene/pseudogene)
• Synonyms
  • CKR-5
  • CC-CKR-5
  • CKR5
  • CD195
  • IDDM22
• Locus
  3p21.31
• Discovery year
  1996-05-15
• Entrez gene record
  1234
• Pubmed identfication
  • 8639485
  • 9284370
  • 20210993
• RefSeq identity
  • NM_000579
• Classification
  • C-C motif chemokine receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000133481

Gene info

• Identity
  HGNC:1604
• Gene
  CCR3
• Long gene name
  C-C motif chemokine receptor 3
• Synonyms gene
  • CMKBR3
• Synonyms gene name
  • chemokine (C-C motif) receptor 3
• Synonyms
  • CC-CKR-3
  • CKR3
  • CD193
• GenBank acession
  • AF247361
• Locus
  3p21.31
• Discovery year
  1995-05-30
• Entrez gene record
  1232
• Classification
  • C-C motif chemokine receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000133484

Gene info

• Identity
  HGNC:1605
• Gene
  CCR4
• Long gene name
  C-C motif chemokine receptor 4
• Synonyms gene name
  • chemokine (C-C motif) receptor 4
• Synonyms
  • CC-CKR-4
  • CMKBR4
  • CKR4
  • k5-5
  • ChemR13
  • CD194
• GenBank acession
  • X85740
• Locus
  3p22.3
• Discovery year
  1996-05-15
• Entrez gene record
  1233
• Pubmed identfication
  • 7642634
  • 8884276
• Classification
  • C-C motif chemokine receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000130752

Gene info

• Identity
  HGNC:1603
• Gene
  CCR2
• Long gene name
  C-C motif chemokine receptor 2
• Synonyms gene
  • CMKBR2
• Synonyms gene name
  • chemokine (C-C motif) receptor 2
• Synonyms
  • CC-CKR-2
  • CKR2
  • MCP-1-R
  • CD192
  • FLJ78302
• Locus
  3p21.31
• Discovery year
  1995-05-30
• Entrez gene record
  729230
• Pubmed identfication
  • 8146186
• RefSeq identity
  • NM_000647
• Classification
  • C-C motif chemokine receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000156466

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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