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FAS Inhibitor, C75

FAS Inhibitor, C75 is available 1 time from Biovision labs

1547-1 | FAS Inhibitor, C75 size: 1 mg | 199.72 USD

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Alternative_name 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
Description Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of FAS. Down regulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activiate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant in vivo antitumor activity in human breast cancer cells.Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei.
CAS Number 191282-48-1
Structure Available? Yes
Salt Form No
Molecular Formula C₁₄H₂₂O₄
Molecular Weight 254.3
Cell-Permeable? Yes
Purity ≥98%
Solubilities DMSO (18 mg/ml)
Handling Protect from light
Tag Line A FAS inhibitor
Storage Condition -20°C
Shipping Condition RT
Shelf Life 24months
MDL Number MFCD03426157
PubChem CID 9881506
SMILES CCCCCCCCC1C(C(=C)C(=O)O1)C(=O)O
InChi InChI=1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12+/m1/s1
InChi Key VCWLZDVWHQVAJU-NEPJUHHUSA-N
MSDS Available Yes
Additional description Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Gene targetFAS Inhibitor C75
Short name FAS Inhibitor, C75
Alternative name Fas (TNF receptor superfamily, member 6) suppressor, C75
Alternative to gene target Fas (TNF receptor superfamily, member 6), ALPS1A and APO-1 and APT1 and CD95 and FAS1 and FASTM and TNFRSF6, FAS and IDBG-81669 and ENSG00000026103 and 355, identical protein binding, nuclei, Fas and IDBG-159577 and ENSMUSG00000024778 and 14102, FAS and IDBG-637356 and ENSBTAG00000010785 and 282488
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