Naquotinib

• Catalog number
  B1317-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (R)-5-((1-acryloylpyrrolidin-3-yl)oxy)-6-ethyl-3-((4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrazine-2-carboxamide; ASP8273
• Description
  Naquotinib is a potent, irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor that displays antineoplastic activity. Naquotinib preferentially inhibits mutated forms of EGFR including T790M, a secondarily acquired resistance mutation, and may have therapeutic benefits in tumors with T790M-mediated resistance when compared to other EGFR tyrosine kinase inhibitors.
• CAS Number
  448232-80-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₀H₄₂N₈O₃
• Molecular Weight
  562.72
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent, irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  71667668
• PubChem CID Link
• SMILES
  CCC1=NC(=C(N=C1OC2CCN(C2)C(=O)C=C)NC3=CC=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)C(=O)N
• InChi
  CCC1=NC(=C(N=C1O[C@@H]2CCN(C2)C(=O)C=C)NC3=CC=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)C(=O)N
• InChi Key
  QKDCLUARMDUUKN-XMMPIXPASA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Naquotinib  
• Short name
  Naquotinib
• Alternative name
  Naquotinib

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