MADH7 Antibody
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Catalog numberPA1954
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PricePlease ask
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Size0,1 mg
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Target antigenMADH7
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ClonalityPolyclonal antibody
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ClonePolyclonal antibody
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Raised inrabbit
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Type of the antibodyIgG polyclonal antibody
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Product formfreeze-dried
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Reacts with specieshuman
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AnalysesWB,IHC-P
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ImmunogenA synthetic peptide corresponding to a sequence at the C-terminus of human MADH7(375-389aa YSLQRPNDHEFMQQP), identical to the related rat and mouse sequences.
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Product configurationEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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PurificationImmunogen affinity purified.
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SolubilizationThe powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtionsKeep the MADH7 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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TipsThe MADH7 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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BackgroundSMAD7(Mother against decapentaplegic drosophila homolog of 7), also known as MADH7 or SMA- AND MAD-RELATED PROTEIN 7, is a protein that in humans is encoded by the SMAD7 gene. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of ligands. By somatic cell hybrid analysis, Topper et al.(1997) mapped the MADH7 gene to human chromosome 18. Topper et al.(1997) demonstrated that MADH7 and MADH6 could form complexes in endothelial cells. MADH7 was induced in cultured vascular endothelium by fluid mechanical forces and was capable of modulating endothelial gene expression in response to both humoral and biomechanical stimuli in vitro. By FISH, Roijer et al.(1998) refined the localization to 18q21.1. Lallemand et al.(2001) showed that cells stably expressing SMAD7 had increased susceptibility to apoptosis induced by TGFB, TNFA, serum withdrawal, or loss of cell adhesion.
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Related articles1. Lallemand, F., Mazars, A., Prunier, C., Bertrand, F., Kornprost, M., Gallea, S., Roman-Roman, S., Cherqui, G., Atfi, A. Smad7 inhibits the survival nuclear factor kappa-B and potentiates apoptosis in epithelial cells. Oncogene 20: 879-884, 2001. 2. Roijer, E., Moren, A., ten Dijke, P., Stenman, G. Assignment of the Smad7 gene (MADH7) to human chromosome 18q21.1 by fluorescence in situ hybridization. Cytogenet. Cell Genet. 81: 189-190, 1998. 3. Topper, J. N., Cai, J., Qiu, Y., Anderson, K. R., Xu, Y.-Y., Deeds, J. D., Feeley, R., Gimeno, C. J., Woolf, E. A., Tayber, O., Mays, G. G., Sampson, B. A., Schoen, F. J., Gimbrone, M. A., Jr., Falb, D. Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc. Nat. Acad. Sci. 94: 9314-9319, 1997.
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Gene NameSMAD7
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Protein NameMothers against decapentaplegic homolog 7
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Gene Full NameSMAD family member 7
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SynonymsFLJ16482 antibody|hSMAD 7 antibody|hSMAD7 antibody|MAD(mothers against decapentaplegic Drosophila) homolog 7 antibody|MAD antibody|Mad homolog 7 antibody|MAD homolog 8 antibody|MAD mothers against decapentaplegic homolog 7 antibody|MADH 7 antibody|MADH 8 antibody|MADH6 antibody|MADH8 antibody|Mothers Against Decapentaplegic Drosophila Homolog of 6 antibody|Mothers Against Decapentaplegic Drosophila Homolog of 7 antibody|Mothers against decapentaplegic homolog 7 antibody|Mothers against decapentaplegic homolog 8 antibody|Mothers against DPP homolog 7 antibody|Mothers against DPP homolog 8 antibody|SMA- AND MAD-RELATED PROTEIN 7 antibody|SMAD 7 antibody|SMAD antibody|SMAD family member 7 antibody|SMAD, mothers against DPP homolog 7(Drosophila) antibody|SMAD, mothers against DPP homolog 7 antibody|SMAD6 antibody|SMAD7 antibody|SMAD7_HUMAN antibody
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Uniprot IDO15105
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PropertiesIf you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolSMAD7, SMAD6
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Short nameMADH7 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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Alternative nameMADH7 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameSMAD family member 7
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Synonyms gene
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Synonyms gene name
- MAD, mothers against decapentaplegic homolog 7 (Drosophila)
- SMAD, mothers against DPP homolog 7 (Drosophila)
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GenBank acession
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Locus
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Discovery year1997-08-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- SMAD family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameSMAD family member 6
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Synonyms gene
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Synonyms gene name
- MAD, mothers against decapentaplegic homolog 6 (Drosophila)
- SMAD, mothers against DPP homolog 6 (Drosophila)
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-08-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- SMAD family
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
