Recombinant Mouse Podoplanin / PDPN Protein (His & Fc tag) 100µg

• Catalog number
  PKSM040777-100µg
• Price
  Please ask
• Size
  100µg

• Activity
  Immobilized mouse PDPN-Fch at 10 μg/ml (100 μl/well) can bind biotinylated human CLEC1B-His, The EC50 of biotinylated human CLEC1B-His is 0.04-0.08 μg/ml.
• Synonym
  Gp38;OTS-8;RANDAM-2;T1-alpha;T1a;T1alpha
• Sequence
  Met 1-Leu 141
• Fusion tag
  C-His & Fc
• Accession
  NP_034459.2
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 97 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  40.6 kDa
• AP Mol Mass
  60-65 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Podoplanin   PDPN   Protein   His   tag   100µg  
• Gene symbol
  PDPN
• Short name
  Recombinant Mouse Podoplanin / PDPN Protein (His & Fc tag) 100µg
• Technique
  Recombinant, Mouse, FC, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse Podoplanin / podoplanin Protein (histidine & fragment c detection labelled) 100µg
• Alternative technique
  rec, murine
• Alternative to gene target
  podoplanin, AGGRUS and GP36 and Gp38 and GP40 and HT1A-1 and OTS8 and PA2.26 and T1A and T1A-2 and T1A2 and TI1A, PDPN and IDBG-90582 and ENSG00000162493 and 10630, Cell surfaces, Pdpn and IDBG-202630 and ENSMUSG00000028583 and 14726, BOVAGGRUS and IDBG-636063 and ENSBTAG00000001788 and 509732

Gene info

• Identity
  HGNC:29602
• Gene
  PDPN
• Long gene name
  podoplanin
• Synonyms
  • T1A-2
  • Gp38
  • aggrus
  • GP40
  • PA2.26
  • D2-40
• Synonyms name
  • lung type I cell membrane associated glycoprotein
• GenBank acession
  • AB127958
  • AY194238
• Locus
  1p36.21
• Discovery year
  2005-07-08
• Entrez gene record
  10630
• Pubmed identfication
  • 10393083
  • 9651190
• RefSeq identity
  • NM_006474
• VEGA ID
  OTTHUMG00000007912

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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