NVP-BKM120

• Catalog number
  2619-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine; BKM-120; Buparlisib
• Description
  NVP-BKM120 is a potent inhibitor of class I PI3K isoforms; potently blocks both p110α (IC₅₀ = 52 nM) and p110β (IC₅₀ = 166 nM) in vitro. It is much less effective against the class III PI3K Vps34 and mammalian target of rapamycin (mTOR) and has no effect on PI4Kβ and several other kinases. NVP-BKM120 prevents the growth of assorted cancer cell lines when used at 5 μM and inhibits tumor growth in vivo.
• CAS Number
  944396-07-0
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₁₈H₂₁F₃N₆O₂
• Molecular Weight
  410.39
• Cell Permeable
  Yes
• Purity
  >95% by HPLC
• Solubilities
  DMSO (~15 mg/ml) or EtOH (~15 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent PI3K inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• PubChem CID
  16654980
• PubChem CID Link
• SMILES
  C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4
• InChi
  InChI=1S/C18H21F3N6O2/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27/h9-11H,1-8H2,(H2,22,23)
• InChi Key
  CWHUFRVAEUJCEF-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  NVP-BKM120  
• Short name
  NVP-BKM120
• Alternative name
  NVP-BKM120

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