FGFR1(Tyr653 + Tyr654) Antibody, ALEXA FLUOR 594

• Catalog number
  bs-3205R-A594
• Price
  Please ask
• Size
  100ul

• Long name
  FGFR1(Tyr653 + Tyr654) Antibody, ALEXA FLUOR 594 Conjugated
• Also known as
  Anti-FGFR1 Tyr653 + Tyr654 PAb ALEXA FLUOR 594
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 594
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  FGFR1 Tyr653 + Tyr654
• Specificity
  This is a highly specific antibody against FGFR1 Tyr653 + Tyr654.
• Modification
  Phosphorylation
• Modification Site
  Tyr653 + Tyr654
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  635-660/822
• Subcellular location
  Cytoplasm
• Source
  KLH conjugated synthetic phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyr653/654
• Gene ID Number
  2260
• Swiss Prot
  P11362
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  590nm/617nm
• Synonyms
  CEK; FLG; HH2; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; Fibroblast growth factor receptor 1; Basic fibroblast growth factor receptor 1; Fms-like tyrosine kinase 2; Proto-oncogene c-Fgr; FGFR1
• Properties
  For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• French translation
  anticorps

• Gene target
  FGFR1   Tyr653   Tyr654  
• Gene symbol
  FGFR1
• Short name
  Anti-FGFR1 Tyr653 + Tyr654
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  FGFR1(Tyr653 + Tyr654) Antibody, ALEXA FLUOR 594
• Alternative technique
  antibodies
• Alternative to gene target
  fibroblast growth factor receptor 1, bFGF-R-1 and BFGFR and CD331 and CEK and FGFBR and FGFR-1 and FLG and FLT-2 and FLT2 and HBGFR and HH2 and HRTFDS and KAL2 and N-SAM and OGD, FGFR1 and IDBG-17796 and ENSG00000077782 and 2260, transferase activity, nuclei, Fgfr1 and IDBG-143767 and ENSMUSG00000031565 and 14182, FGFR1 and IDBG-629273 and ENSBTAG00000015457 and 281768

Gene info

• Identity
  HGNC:3688
• Gene
  FGFR1
• Long gene name
  fibroblast growth factor receptor 1
• Synonyms gene
  • FLT2
  • KAL2
• Synonyms gene name
  • fms-related tyrosine kinase 2
• Synonyms
  • H2
  • H3
  • H4
  • H5
  • CEK
  • FLG
  • BFGFR
  • N-SAM
  • CD331
• Synonyms name
  • Pfeiffer syndrome
• GenBank acession
  • M34185
• Locus
  8p11.23
• Discovery year
  1992-02-25
• Entrez gene record
  2260
• Pubmed identfication
  • 2162671
• Classification
  • I-set domain containing
  • Receptor tyrosine kinases
  • CD molecules
• VEGA ID
  OTTHUMG00000147366
• Locus Specific Databases
  • LRG_993

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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