SNX-2112

Alternative_name

2-[(trans-4-Hydroxycyclohexyl)amino]-4-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]benzamide; PF-04928473
Description

SNX-2112 is a potent heat-shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. SNX-2112 selectively accumulates in tumors compared to normal tissues and binds to the N-terminal adenosine triphosphate binding site of Hsp90, inhibiting its activity. This results in the proteasomal degradation of oncogenic client proteins, which prevents signaling through these client proteins, induces apoptosis and inhibits tumor cell proliferation.
CAS Number

908112-43-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₃H₂₇F₃N₄O₃
Molecular Weight

464.48
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>50 mg/ml)
Handling

Protect from air and light
Tag Line

Aotent heat-shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

24772860
PubChem CID Link
SMILES

CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C
InChi

InChI=1S/C23H27F3N4O3/c1-22(2)10-17-19(18(32)11-22)20(23(24,25)26)29-30(17)13-5-8-15(21(27)33)16(9-13)28-12-3-6-14(31)7-4-12/h5,8-9,12,14,28,31H,3-4,6-7,10-11H2,1-2H3,(H2,27,33)
InChi Key

ZFVRYNYOPQZKDG-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes