KW-2449 hydrochloride

• Catalog number
  B1208-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
• Description
  KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. It displays potent inhibition of growth effects on leukemia cells with FLT3 mutations via inhibition of the FLT3 kinase. This leads in the down-regulation of phosphorylated-FLT3/STAT5, G1 arrest, and apoptosis. KW 2449 induces the reduction of phosphorylated histone H3, G2/M arrest, and apoptosis in FLT3 wild-type human leukemia.
• CAS Number
  1000669-72-6
• Structure Available
  Yes
• Salt Form
  Yes
• Molecular Formula
  C₂₀H₂₀N₄O. HCl
• Molecular Weight
  368.86
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO(>30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD18385006
• PubChem CID
  11427553
• PubChem CID Link
• SMILES
  C1CN(CCN1)C(=O)C2=CC=C(C=C2)C=CC3=NNC4=CC=CC=C43
• InChi
  InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+
• InChi Key
  YYLKKYCXAOBSRM-JXMROGBWSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  KW-2449   hydrochloride  
• Short name
  KW-2449 hydrochloride
• Alternative name
  KW-2449 hydrochloride

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