Human CellExp™ 4-1BB Ligand/TNFSF9, Human recombinant
-
Catalog number9240-10
-
PricePlease ask
-
Size10 µg
-
-
Synonyms4-1BB Ligand, TNFSF9, CD137L
-
Alternative_namesTNFSF9, CD137L
-
DescriptionA transmembrane cytokine
-
RecombinantYes
-
SourceHEK 293 cells
-
Purity by SDS PAGE>95%
-
Assay>95%
-
Purity>95%
-
Endotoxin Level< 1 EU/ug
-
Activity Specifications test methodMeasured by its binding ability in a functional ELISA.
-
Biological activityMeasured by its binding ability in a functional ELISA. Immobilized Human 4-1BB, His Tag at 100 ng/mL (100 µl/well), can bind Human 4-1BB Ligand, Fc Tag with a linear of 0.1-2.5 ng/ml and immobilized Human 4-1BB Ligand, Fc Tag at 2u g/ml (100 µl/well), can bind Biotinylated Human 4-1BB, Fc Tag with a linear of 0.5-20 ng/ml.
-
Binding CapacityMeasured by its binding ability in a functional ELISA. Immobilized Human 4-1BB, His Tag at 100 ng/mL (100 µl/well), can bind Human 4-1BB Ligand, Fc Tag with a linear of 0.1-2.5 ng/ml and immobilized Human 4-1BB Ligand, Fc Tag at 2u g/ml (100 µl/well), can bind Biotinylated Human 4-1BB, Fc Tag with a linear of 0.5-20 ng/ml.
-
Molecular WeightThis protein is fused with a Fc tag at C-terminus and has a calculated MW of 47.4 kDa.
-
Storage Temp-20°C
-
ShippingGel pack
-
Shelf Life12 months
-
AppearanceLyophilized
-
Physical form descriptionLyophilized
-
Reconstitution InstructionsReconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml
-
Background InformationTumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
-
HandlingCentrifuge the vial prior to opening.
-
UsageFor Research Use Only! Not to be used in humans
-
PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Additional descriptionFAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
-
Additional sourceRecombinants or rec. proteins
-
Grouprecombinants
-
Gene target
-
Gene symbolTNFSF9, TNFRSF9, MIR1302-4, PIRC18, PIRC16, SNORD114-4, MIR941-4, IGKV2OR2-4
-
Short nameCellExp™ 4-1BB Ligand/TNFSF9, recombinant
-
TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
SpeciesHumans
-
Alternative nameH. sapiens CellExp™ 4-1BB Ligand/tumor necrosis factor (ligand) superfamily, member 9, H. sapiens Rec.
-
Alternative techniquerec
-
Alternative to gene targettumor necrosis factor (ligand) superfamily, member 9, 4-1BB-L and CD137L, TNFSF9 and IDBG-21688 and ENSG00000125657 and 8744, tumor necrosis factor receptor superfamily binding, Extracellular, Tnfsf9 and IDBG-193693 and ENSMUSG00000035678 and 21950, TNFSF9 and IDBG-643947 and ENSBTAG00000046266 and 521748
-
Gene info
-
Identity
-
Gene
-
Long gene nameTNF superfamily member 9
-
Synonyms gene name
- tumor necrosis factor (ligand) superfamily, member 9
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1998-12-04
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Tumor necrosis factor superfamily
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameTNF receptor superfamily member 9
-
Synonyms gene
-
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 9
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1996-06-12
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Tumor necrosis factor receptor superfamily
- CD molecules
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 1302-4
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2008-11-03
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR1302 family
Gene info
-
Identity
-
Gene
-
Long gene namepiwi-interacting RNA cluster 18
-
Locus
-
Discovery year2009-11-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Piwi-interacting RNA clusters
Gene info
-
Identity
-
Gene
-
Long gene namepiwi-interacting RNA cluster 16
-
Locus
-
Discovery year2009-11-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Piwi-interacting RNA clusters
Gene info
-
Identity
-
Gene
-
Long gene namesmall nucleolar RNA, C/D box 114-4
-
Synonyms
-
Locus
-
Discovery year2006-09-26
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Small nucleolar RNAs, C/D box
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 941-4
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2007-10-24
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNAs
Gene info
-
Identity
-
Gene
-
Long gene nameimmunoglobulin kappa variable 2/OR2-4 (pseudogene)
-
Synonyms gene name
- immunoglobulin kappa variable 2/OR2-4
- immunoglobulin kappa variable 2/OR2-4 pseudogene
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2000-04-18
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Immunoglobulin kappa (IGK) orphons
MeSH Data
-
Name
-
ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
