JNJ-7706621

• Catalog number
  B1941-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  4-[[5-amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide
• Description
  JNJ-7706621 is a potent inhibitor of cyclin-dependent kinases (CDK) and Aurora kinases with IC₅₀ values of 9 nM, 4 nM, 11 nM and 15 nM for CDK1, 2 and Aurora A, B, respectively. In vitro assays shows that JNJ-7706621 inhibits glioblastoma cellular viability, proliferation, and migration via inducing glioblastoma cells apoptosis.
• CAS Number
  443797-96-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₅H₁₂F₂N₆O₃S
• Molecular Weight
  394.36
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>18 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent inhibitor of cyclin-dependent kinases (CDK) and Aurora kinases
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  5330790
• PubChem CID Link
• SMILES
  C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F
• InChi
  InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
• InChi Key
  KDKUVYLMPJIGKA-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  JNJ-7706621  
• Short name
  JNJ-7706621
• Alternative name
  JNJ-7706621

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