CPI-203

Alternative_name

(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Description

CPI-203 is an analog of (+)-JQ1 (Cat. No. 2070). Acts as a BET bromodomain inhibitor. It is comparable or superior to (+)-JQ1 in inhibiting BRD4 binding and action in vitro or in cells.CPI-203 arrests the growth of leukemic T cells in vitro (EC₅₀ = 91 nM) and rapidly suppresses leukemia burden in mice.
CAS Number

1446144-04-2
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₉H₁₈ClN₅OS
Molecular Weight

399.9
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>35 mg/ml)
Handling

Protect from air and light
Tag Line

A BET bromodomain inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

71291068
PubChem CID Link
SMILES

CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)N)C4=CC=C(C=C4)Cl)C
InChi

InChI=1S/C19H18ClN5OS/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)22-14(8-15(21)26)18-24-23-11(3)25(18)19/h4-7,14H,8H2,1-3H3,(H2,21,26)/t14-/m0/s1
InChi Key

QECMENZMDBOLDR-AWEZNQCLSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:21365
Gene

LYRM4
Long gene name

LYR motif containing 4
Synonyms gene
- C6orf149
Synonyms gene name
- chromosome 6 open reading frame 149
Synonyms
- CGI-203
- ISD11
GenBank acession
- AF258559
Locus

6p25.1
Discovery year

2003-06-10
Entrez gene record

57128
Pubmed identfication
- 23814038
RefSeq identity
- NM_020408
Classification
- LYR motif containing
- Mitochondrial iron-sulfur assembly components
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000014173