L1CAM Antibody

• Catalog number
  F44598-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  L1CAM
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000 (1)
• Notes
  Titration of the L1CAM antibody may be required due to differences in protocols and secondary/substrate sensitivity.1. Cleavage by ADAM10 results in 180 and 40 kDa bands while cleavage by Plasmin results in 140 and 80 kDa bands.
• Intented use
  This L1CAM antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P32004
• Purity
  Antigen affinity
• Description
  L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
• Immunogen
  A portion of amino acids 1154-1182 from the human protein was used as the immunogen for this L1CAM antibody.
• Storage
  Aliquot the L1CAM antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  L1CAM  
• Gene symbol
  L1CAM-AS1, L1CAM
• Short name
  Anti-L1CAM
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to L1CAM
• Alternative technique
  antibodies
• Alternative to gene target
  L1 cell adhesion molecule, CAML1 and CD171 and HSAS and HSAS1 and MASA and MIC5 and N-CAM-L1 and N-CAML1 and NCAM-L1 and S10 and SPG1, L1CAM and IDBG-90096 and ENSG00000198910 and 3897, protein self-association, Cell surfaces, L1cam and IDBG-154012 and ENSMUSG00000031391 and 16728, L1CAM and IDBG-632479 and ENSBTAG00000013462 and 516017

Gene info

• Identity
  HGNC:55247
• Gene
  L1CAM-AS1
• Long gene name
  L1CAM antisense RNA 1
• Synonyms
  • LCA10
• Synonyms name
  • lung carcinoma-associated 10
• Locus
  Xq28
• Discovery year
  2021-09-02
• Entrez gene record
  100996465
• Pubmed identfication
  • 15689435
• RefSeq identity
  • NR_130768
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:6470
• Gene
  L1CAM
• Long gene name
  L1 cell adhesion molecule
• Synonyms gene
  • HSAS1
  • SPG1
  • HSAS
  • MASA
  • MIC5
  • S10
• Synonyms gene name
  • antigen identified by monoclonal antibody R1
• Synonyms
  • CD171
  • NCAM-L1
  • CAML1
• Synonyms name
  • neural cell adhesion molecule L1
• GenBank acession
  • M74387
• Locus
  Xq28
• Discovery year
  1989-06-30
• Entrez gene record
  3897
• RefSeq identity
  • NM_024003
• Classification
  • Ig-like cell adhesion molecule family
  • I-set domain containing
  • Fibronectin type III domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000024221
• Locus Specific Databases
  • Global Variome shared LOVD
  • NGRL, Manchester LOVD
  • Global Variome shared LOVD
  • LRG_14

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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