Grazoprevir (MK-5172)

• Catalog number
  B2337-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  MK-5172,(33R,35S,91R,92R,5S)-5-(tert-butyl)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxamide
• Description
  Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). Grazoprevir is a second-generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets. It has good activity against a range of HCV genotype variants, including some that are resistant to most currently used antiviral medications.
• CAS Number
  1350514-68-9
• Structure Available
  Yes
• Molecular Formula
  C₃₈H₅₀N₆O₉S
• Molecular Weight
  766.91
• Cell Permeable
  1
• Purity
  ≥98% by HPLC
• Solubilities
  >25 mg/ml (DMSO)
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  Hepatitis C virus NS3/4A Protease Inhibitor
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  44603531
• PubChem CID Link
• SMILES
  CC(C)(C)C1C(=O)N2CC(CC2C(=O)NC3(CC3C=C)C(=O)NS(=O)(=O)C4CC4)OC5=NC6=C(C=CC(=C6)OC)N=C5CCCCCC7CC7OC(=O)N1
• InChi
  InChI=1S/C38H50N6O9S/c1-6-22-19-38(22,35(47)43-54(49,50)25-13-14-25)42-32(45)29-18-24-20-44(29)34(46)31(37(2,3)4)41-36(48)53-30-16-21(30)10-8-7-9-11-27-33(52-24)40-28-17-23(51-5)12-15-26(28)39-27/h6,12,15,17,21-22,24-25,29-31H,1,7-11,13-14,16,18-20H2,2-5H3,(H,41,48)(H,42,45)(H,43,47)/t21-,22-,24-,29+,30-,31-,38-/m1/s1
• InChi Key
  OBMNJSNZOWALQB-NCQNOWPTSA-N
• Data Sheet Link
• MSDS Available
  1

• Gene target
  Grazoprevir   MK-5172  
• Gene symbol
  MVK, STYXL1, MDK, MAPKAPK3, EPCAM
• Short name
  Grazoprevir (MK-5172)
• Alternative name
  Grazoprevir (MK-5172)

Gene info

• Identity
  HGNC:7530
• Gene
  MVK
• Long gene name
  mevalonate kinase
• Synonyms gene name
  • mevalonate kinase (mevalonic aciduria)
• Synonyms
  • LRBP
  • MK
• Synonyms name
  • LH receptor mRNA-binding protein
  • mevalonic aciduria
• GenBank acession
  • M88468
• Locus
  12q24.11
• Discovery year
  1992-10-06
• Entrez gene record
  4598
• Pubmed identfication
  • 1377680
• RefSeq identity
  • NM_000431
• VEGA ID
  OTTHUMG00000169256
• Locus Specific Databases
  • INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
  • LRG_156

Gene info

• Identity
  HGNC:18165
• Gene
  STYXL1
• Long gene name
  serine/threonine/tyrosine interacting like 1
• Synonyms gene
  • DUSP24
• Synonyms gene name
  • dual specificity phosphatase 24 (putative)
• Synonyms
  • MK-STYX
• GenBank acession
  • AF069762
• Locus
  7q11.23
• Discovery year
  2005-01-20
• Entrez gene record
  51657
• Pubmed identfication
  • 9757831
• RefSeq identity
  • NM_016086
• Classification
  • MAP kinase phosphatases
• VEGA ID
  OTTHUMG00000130459

Gene info

• Identity
  HGNC:6972
• Gene
  MDK
• Long gene name
  midkine
• Synonyms gene
  • NEGF2
• Synonyms gene name
  • neurite growth-promoting factor 2
• Synonyms
  • MK
  • FLJ27379
• Locus
  11p11.2
• Discovery year
  1991-07-10
• Entrez gene record
  4192
• Pubmed identfication
  • 8406506
• RefSeq identity
  • NM_001012334
• VEGA ID
  OTTHUMG00000150315

Gene info

• Identity
  HGNC:6888
• Gene
  MAPKAPK3
• Long gene name
  MAPK activated protein kinase 3
• Synonyms gene name
  • mitogen-activated protein kinase-activated protein kinase 3
• Synonyms
  • 3pK
  • MAPKAP3
  • 3PK
  • MK-3
  • MK3
• GenBank acession
  • U43784
• Locus
  3p21.2
• Discovery year
  1999-03-26
• Entrez gene record
  7867
• Pubmed identfication
  • 8626550
  • 8622688
• RefSeq identity
  • NM_004635
• Classification
  • MAPK activated protein kinases
• VEGA ID
  OTTHUMG00000156850

Gene info

• Identity
  HGNC:11529
• Gene
  EPCAM
• Long gene name
  epithelial cell adhesion molecule
• Synonyms gene
  • M4S1
  • MIC18
  • TACSTD1
• Synonyms gene name
  • antigen identified by monoclonal antibody AUA1
  • tumor-associated calcium signal transducer 1
• Synonyms
  • Ly74
  • TROP1
  • GA733-2
  • EGP34
  • EGP40
  • EGP-2
  • KSA
  • CD326
  • Ep-CAM
  • HEA125
  • KS1/4
  • MK-1
  • MH99
  • MOC31
  • MOC-31
  • 323/A3
  • 17-1A
  • TACST-1
  • CO-17A
  • ESA
  • BerEp4
  • Ber-Ep4
• Synonyms name
  • trophoblast cell surface antigen 1
• GenBank acession
  • M33011
• Locus
  2p21
• Discovery year
  1995-10-02
• Entrez gene record
  4072
• Pubmed identfication
  • 8382772
  • 11306819
• Classification
  • MicroRNA protein coding host genes
  • CD molecules
• VEGA ID
  OTTHUMG00000128853
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_215

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