PITX2 Antibody

• Catalog number
  F43713-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  PITX2
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IF, ELISA
• Recommended dilutions
  Immunofluorescence: 1:10-1:50,Western blot: 1:1000
• Notes
  Titration of the PITX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This PITX2 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q99697
• Purity
  Antigen affinity
• Description
  Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.
• Immunogen
  A portion of amino acids 122-151 from the human protein was used as the immunogen for this PITX2 antibody.
• Storage
  Aliquot the PITX2 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PITX2  
• Gene symbol
  PITX2
• Short name
  Anti-PITX2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to PITX2
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9005
• Gene
  PITX2
• Long gene name
  paired like homeodomain 2
• Synonyms gene
  • IRID2
  • IHG2
  • RIEG
  • RIEG1
  • RGS
• Synonyms gene name
  • paired-like homeodomain transcription factor 2
  • paired-like homeodomain 2
• Synonyms
  • IGDS
  • RS
  • Brx1
  • Otlx2
  • ARP1
• GenBank acession
  • U69961
• Locus
  4q25
• Discovery year
  1992-10-05
• Entrez gene record
  5308
• Pubmed identfication
  • 9539779
  • 7581385
• Classification
  • PRD class homeoboxes and pseudogenes
• VEGA ID
  OTTHUMG00000132837

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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