AVN-944

Alternative_name

(R)-1-cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate; VX-944
Description

AVN-944 is a potent inosine 5-monophosphate dehydrogenase (IMPDH) inhibitor that displays anticancer activities. AVN-944 inhibits the growth of human prostate cancer cells by inducing cell cycle arrest, cell death as well as differentiation.
CAS Number

297730-17-7
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₅H₂₇N₅O₅
Molecular Weight

477.51
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent inosine 5-monophosphate dehydrogenase (IMPDH) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

9918559
PubChem CID Link
SMILES

CCC(CC#N)OC(=O)NC(C)C1=CC(=CC=C1)NC(=O)NC2=CC(=C(C=C2)C3=CN=CO3)OC
InChi

InChI=1S/C25H27N5O5/c1-4-20(10-11-26)35-25(32)28-16(2)17-6-5-7-18(12-17)29-24(31)30-19-8-9-21(22(13-19)33-3)23-14-27-15-34-23/h5-9,12-16,20H,4,10H2,1-3H3,(H,28,32)(H2,29,30,31)/t16-,20+/m0/s1
InChi Key

GYCPCOJTCINIFZ-OXJNMPFZSA-N
Data Sheet Link
MSDS Available

Yes