YM-90709

Alternative_name

5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-b]quinoxaline
Description

YM-90709 is a selective inhibitor of interleukin-5 (IL-5). YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC₅₀ values of 1.0 and 0.57 µM, respectively. In functional assays, YM-90709 inhibits IL-5-prolonged eosinophil survival with an IC₅₀ value of 0.45 µM and does not affect the GM-CSF-prolonged eosinophil survival.
CAS Number

163769-88-8
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₂H₂₁N₃O₂
Molecular Weight

359.43
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>15 mg/ml)
Handling

Protect from air and light
Tag Line

YM-90709 is a novel, selective inhibitor of interleukin-5 (IL-5).
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

1103147
PubChem CID Link
SMILES

CC1(CC2=CC(=C(C=C2C3=CC4=NC5=CC=CC=C5N=C4N31)OC)OC)C
InChi

InChI=1S/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3
InChi Key

HIXSPVQXXDULHS-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes