Myeloperoxidase Inhibitor
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Catalog number
1977-500
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Price
Please ask
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Size
500 mg
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Alternative_name
4-Aminobenzoic hydrazide; MPO Inhibitor; 4-ABH
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Description
A potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC₅₀ = 300 nM). Does not affect catalase or glutathione peroxidase activities. Also displays no effect on the production of superoxide by neutrophils. Shown to inhibit H₂O₂-induced apoptosis in HL-60, human leukemia cells.
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CAS Number
5351-17-7
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₇H9N₃O
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Molecular Weight
151.17
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Cell Permeable
Yes
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Purity
≥95% by HPLC
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Solubilities
DMSO
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Handling
Protect from light and mositure
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Tag Line
A potent myeloperoxidase (MPO) inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
48 months
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MDL Number
MFCD00007606
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PubChem CID
21450
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SMILES
C1=CC(=CC=C1C(=O)NN)N
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InChi
InChI=1S/C7H9N3O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,8-9H2,(H,10,11)
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InChi Key
WPBZMCGPFHZRHJ-UHFFFAOYSA-N
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MSDS Available
Yes
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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