Calpain Inhibitor II, ALLM
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Catalog number
1835-5
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Price
Please ask
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Size
5 mg
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Alternative_name
Ac-LLM-CHO, N-Acetyl-Leu-Leu-Methional
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Description
A cell-permeable inhibitor of calpain 1 (Ki = 120 nM) and calpain 2 (Ki = 230 nM). Also potently inhibits cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Shown to induce caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin’s Lymphoma cells.
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CAS Number
136632-32-1
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Structure Available
Yes
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Peptide sequence
N-Acetyl-Leu-Leu-Methional
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Salt Form
No
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Molecular Formula
C₁₉H₃₅N₃O₄S
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Molecular Weight
401.57
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Cell Permeable
Yes
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Purity
≥95% by HPLC
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Solubilities
DMSO (25 mg/ml) or EtOH (25 mg/ml)
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Handling
Protect from moisture and air
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Tag Line
A Calpain inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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MDL Number
MFCD00065506
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PubChem CID
4331
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SMILES
CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCSC)C=O)NC(=O)C
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InChi
InChI=1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18 (25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21, 25)(H,22,26)
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InChi Key
RJWLAIMXRBDUMH-UHFFFAOYSA-N
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MSDS Available
Yes
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Short name
Calpain Inhibitor II, ALLM
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Alternative name
Calpain suppressor II, ALLM
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