GSK-2126458

• Catalog number
  1961-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  2,4-Difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide
• Description
  Cell-permeable. A highly potent, pan phosphoinositide 3-kinase (PI 3-K) family kinase inhibitor with biochemical Ki’s of 0.019 nM (PI 3-K⍺), 0.13 nM (PI 3-Kβ), 0.024 nM (PI 3-Kδ), 0.06 nM (PI 3-Kɣ), 0.18 nM (mTORC1), and 0.3 nM (mTORC2). In vivo, GSK2126458 displays anti-tumor activity in both pharmacodynamic and tumor growth efficacy models.
• CAS Number
  1086062-66-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₅H₁₇F₂N₅O₃S
• Molecular Weight
  505.5
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 5 mg/ml)
• Handling
  Protect from light and air
• Tag Line
  A PI3 Kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  48 months
• MDL Number
  MFCD16038929
• PubChem CID
  25167777
• PubChem CID Link
• SMILES
  COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F
• InChi
  InChI=1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3
• InChi Key
  CGBJSGAELGCMKE-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GSK-2126458  
• Short name
  GSK-2126458
• Alternative name
  GSK-2126458

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