Jarid2/Jumonji Antibody, ALEXA FLUOR 488

• Catalog number
  bs-11860R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  Jarid2/Jumonji Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-Jarid2/Jumonji PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Jarid2/Jumonji
• Specificity
  This is a highly specific antibody against Jarid2/Jumonji.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  315-365/1246
• Subcellular location
  Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Jarid2/Jumonji
• Gene ID Number
  3720
• Swiss Prot
  Q92833
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  JMJ; Protein Jumonji; Jumonji/ARID domain-containing protein 2; JARID2
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-Jarid2/Jumonji has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  Jarid2/Jumonji  
• Gene symbol
  JARID2
• Short name
  Anti-Jarid2/Jumonji
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  Jarid2/Jumonji Polyclonal Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies
• Alternative to gene target
  jumonji, AT rich interactive domain 2, JMJ, JARID2 and IDBG-62820 and ENSG00000008083 and 3720, protein binding, nuclei, Jarid2 and IDBG-147776 and ENSMUSG00000038518 and 16468, JARID2 and IDBG-636025 and ENSBTAG00000012938 and 528253

Gene info

• Identity
  HGNC:6196
• Gene
  JARID2
• Long gene name
  jumonji and AT-rich interaction domain containing 2
• Synonyms gene
  • JMJ
• Synonyms gene name
  • jumonji (mouse) homolog
  • Jumonji, AT rich interactive domain 2
  • jumonji, AT rich interactive domain 2
• GenBank acession
  • U57592
• Locus
  6p22.3
• Discovery year
  1997-09-05
• Entrez gene record
  3720
• Pubmed identfication
  • 8894700
• RefSeq identity
  • NM_004973
• Classification
  • Iron (II) and 2-oxoglutarate dependent oxygenases
  • AT-rich interaction domain containing
• VEGA ID
  OTTHUMG00000014293

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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