Caspase-2 Antibody

• Catalog number
  3027-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  Caspase-2
• Target Alternative Name
  CASP-2, NEDD-2,NEDD2, ICH1, ICH-1L/1S, ICH-1L, EC 3.4.22.55
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse, rat
• Immunogen Sequence
  Synthetic peptide surrounding amino acid 417 of mouse caspase-2
• Accession
  D28492
• Gene Id
  12366
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.2 mg/ml
• Formulation
  100 µg (0.2 mg/ml) affinity purified rabbit anti-caspase-2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
• Purification
  Affinity purified
• Application
  Western blot, Immunohistochemistry
• Positive Control
  Western Blot: Jurkat cell lysate, treated and untreated. IHC: Placenta tissue.
• Application And Usages
  Western blotting (1-2 µg/ml), and Immunohistochemistry (5 µg/ml). However, the optimal conditions should be determined individually. Detects the full length and small subunit of caspase-2. In human samples, it also detects a 30 kDa intermeadiate fragment
• Description
  Caspases play a key role in apoptosis. Similar as other caspases, caspase-2 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Caspase-2 mRNA is alternatively spliced. The larger mRNA species encoding a product of 435 amino acids is known as ICH-1L. The smaller mRNA species encoding a protein of 312 amino acids is named ICH-1S. Over expression of ICH-1L induces apoptosis, while over expression of ICH-1S suppresses Rat-1 cell death induced by serum deprivation.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Additional description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
• French translation
  anticorps

• Gene target
  Caspase-2  
• Gene symbol
  CASP4, CASP1P2, CASP10
• Short name
  Caspase-2 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  caspase-2 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1505
• Gene
  CASP4
• Long gene name
  caspase 4
• Synonyms gene name
  • caspase 4, apoptosis-related cysteine protease
  • caspase 4, apoptosis-related cysteine peptidase
• Synonyms
  • ICE(rel)II
  • ICH-2
  • TX
• GenBank acession
  • U25804
• Locus
  11q22.3
• Discovery year
  1996-07-22
• Entrez gene record
  837
• Pubmed identfication
  • 7797510
  • 9250871
• RefSeq identity
  • NM_001225
• Classification
  • Caspases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000166078

Gene info

• Identity
  HGNC:43776
• Gene
  CASP1P2
• Long gene name
  caspase 1 pseudogene 2
• Synonyms gene name
  • caspase 1, apoptosis-related cysteine peptidase pseudogene 2
• Locus
  11q22.3
• Discovery year
  2012-02-24
• Entrez gene record
  440067
• RefSeq identity
  • NR_131905
• VEGA ID
  OTTHUMG00000166162

Gene info

• Identity
  HGNC:1500
• Gene
  CASP10
• Long gene name
  caspase 10
• Synonyms gene name
  • caspase 10, apoptosis-related cysteine protease
  • caspase 10, apoptosis-related cysteine peptidase
• Synonyms
  • MCH4
  • FLICE-2
• Synonyms name
  • FAS-associated death domain protein interleukin-1B-converting enzyme 2
• GenBank acession
  • U60519
• Locus
  2q33.1
• Discovery year
  1997-04-21
• Entrez gene record
  843
• Pubmed identfication
  • 8755496
• RefSeq identity
  • NM_032977
• Classification
  • Caspases
  • Death effector domain containing
  • Death inducing signaling complex
• VEGA ID
  OTTHUMG00000132818
• Locus Specific Databases
  • CASP10base: Mutation registry for Autoimmune lymphoproliferative syndrome, type II (ALPS2)
  • LRG_33

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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