Neratinib

• Catalog number
  2023-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  HKI-272
• Description
  Cell-permeable. A second-generation inhibitor of the ErbB family of receptor kinases. Neratinib acts as an irreversible inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2) tyrosine kinases by targeting a cysteine residue in the ATP-binding site of the receptor. It inhibits the proliferation of HER-2 overexpressing human breast cancer cell lines and EGFR-dependent cells in vitro.
• CAS Number
  698387-09-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₀H₂₉ClN₆O₃
• Molecular Weight
  557.04
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 2 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A potent erbB family receptor tyrosine kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD09752958
• PubChem CID
  9915743
• PubChem CID Link
• SMILES
  CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C= CCN(C)C
• InChi
  InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2) 3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33- 22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+
• InChi Key
  JWNPDZNEKVCWMY-VQHVLOKHSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Neratinib  
• Short name
  Neratinib
• Alternative name
  Neratinib

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