BIIB 021
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Catalog number2291-5
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PricePlease ask
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Size5 mg
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Alternative_name6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine; CNF2024
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DescriptionA synthetic, small molecule Hsp90 inhibitor that binds competitively with geldanamycin in the ATP-binding pocket of Hsp90. In tumor cells, BIIB021 induces the degradation of Hsp90 client proteins including HER-2, AKT, and Raf-1 and up-regulates expression of the heat shock proteins Hsp70 and Hsp27. BIIB021 inhibits the proliferation of N87, MCF-7, and BT474 tumor cells with IC₅₀ values of 0.06, 0.31, and 0.14 µM, respectively.
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CAS Number848695-25-0
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Structure AvailableYes
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Peptide sequenceNo
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Salt FormNo
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Molecular FormulaC₁₄H₁₅ClN₆O
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Molecular Weight318.76
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Cell PermeableYes
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Purity≥99% by HPLC
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SolubilitiesDMSO (~65 mg/ml) or EtOH (~3 mg/ml)
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HandlingProtect from light and moisture
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Tag LineA potent Hsp90 inhibitor
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Storage Condition-20 ̊C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD15528939
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PubChem CID16736529
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SMILESCC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N
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InChiInChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20)
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InChi KeyQULDDKSCVCJTPV-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameBIIB 021
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Alternative nameBIIB 021
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