BIIB 021

• Catalog number
  2291-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  6-Chloro-9-[(4-methoxy-3,5-dimethyl­-2-pyridinyl)methyl]-9H-purin-2-amine; CNF2024
• Description
  A synthetic, small molecule Hsp90 inhibitor that binds competitively with geldanamycin in the ATP-binding pocket of Hsp90. In tumor cells, BIIB021 induces the degradation of Hsp90 client proteins including HER-2, AKT, and Raf-1 and up-regulates expression of the heat shock proteins Hsp70 and Hsp27. BIIB021 inhibits the proliferation of N87, MCF-7, and BT474 tumor cells with IC₅₀ values of 0.06, 0.31, and 0.14 µM, respectively.
• CAS Number
  848695-25-0
• Structure Available
  Yes
• Peptide sequence
  No
• Salt Form
  No
• Molecular Formula
  C₁₄H₁₅ClN₆O
• Molecular Weight
  318.76
• Cell Permeable
  Yes
• Purity
  ≥99% by HPLC
• Solubilities
  DMSO (~65 mg/ml) or EtOH (~3 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  A potent Hsp90 inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD15528939
• PubChem CID
  16736529
• PubChem CID Link
• SMILES
  CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N
• InChi
  InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20)
• InChi Key
  QULDDKSCVCJTPV-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  BIIB   021  
• Short name
  BIIB 021
• Alternative name
  BIIB 021

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