NFkB p105 Antibody
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Catalog number3897-200
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PricePlease ask
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Size200 µg
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Antibody TargetNFkB p105
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Target Alternative NameNuclear factor of kappa light polypeptide gene enhancer in B-cells 1, NFkappaB p105, NFkB 105, NFkB105, NFkappaB 105, NFkappaB 105
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Antibody TypePolyclonal
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Species ReactivitiesHuman, mouse, rat
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Immunogen SequenceSynthetic peptide surrounding amino acid 955 of human NFkB105
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AccessionBAF84139
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Gene Id4790
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AppearanceColorless liquid
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FormLiquid
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Concentration0.5 mg/ml
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Formulation200 µg (0.5 mg/ml) purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
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PurificationAffinity purified
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ApplicationWestern blot
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Application And UsagesWestern blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes the 105 kDa NFkB p105 in samples from human, mouse and rat origins. Reactivity to other species has not been determined.
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DescriptionNFkB was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NFkB is activated by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines, and viral infection. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.
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Storage Condition-20 °C
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Shipping Conditiongel pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans.
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HandlingThe antibody solution should be gently mixed before use.
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Western Blot VerifiedVerified
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Immunocytochemistry VerifiedNot Verified
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Immunofluorescence VerifiedNot Verified
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Immunoprecipitation VerifiedNot Verified
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FACS VerifiedNot Verified
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ELISA VerifiedNot Verified
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ChIP VerifiedNot Verified
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Flow Cytometry VerifiedNot Verified
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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GeneNF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory
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French translationanticorps
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Gene target
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Gene symbolNFKB1
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Short nameNFkB p105 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameNFkB p105 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namenuclear factor kappa B subunit 1
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Synonyms gene name
- nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-11-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NF-kappa B complex subunits
- Ankyrin repeat domain containing
- IPT domain containing
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data