RTA-402

Alternative_name

Bardoxolone methyl; CDDO Methyl ester; CDDOMe; NSC 713200; RTA402
Description

RTA-402 is a synthetic triterpenoid compound with anti-inflammatory, antitumor and cytoprotective properties. RTA-402 is a potent nuclear factor erythroid 2-related factor 2 (Nrf2) activator. CDDO-Me has been used for the treatment of chronic kidney disease, cancer (including leukemia and solid tumors), and other diseases.
CAS Number

218600-53-4
Structure Available

Yes
Salt Form

No
Molecular Formula

C₃₂H₄₃NO₄
Molecular Weight

505.69
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~ 5 mg/ml)
Handling

Protect from air and light
Tag Line

A potent nuclear factor erythroid 2-related factor 2 (Nrf2) activator
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD11983137
PubChem CID

400769
PubChem CID Link
SMILES

CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)OC)C
InChi

InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChi Key

WPTTVJLTNAWYAO-KPOXMGGZSA-N
Data Sheet Link
MSDS Available

Yes