anti- MCM6 antibody

• Catalog number
  FNab05061
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.
• Immunogen
  minichromosome maintenance complex component 6
• Calculated MW
  147 kDa
• Uniprot ID
  Q14566
• Specificity
  Human, Mouse, Rat
• Tested Application
  ELISA, WB, IF, IHC
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
• Image1
  Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using FNab05061( MCM6 Antibody) at dilution of 1:50
• Image4
  mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab05061(MCM6 antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MCM6  
• Gene symbol
  MCM6
• Short name
  anti- MCM6 antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- MCM6 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6949
• Gene
  MCM6
• Long gene name
  minichromosome maintenance complex component 6
• Synonyms gene name
  • minichromosome maintenance deficient (mis5, S. pombe) 6
  • MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
  • minichromosome maintenance deficient 6 homolog (S. cerevisiae)
• Synonyms
  • Mis5
• Synonyms name
  • MIS5 homolog (S.pombe)
• Locus
  2q21.3
• Discovery year
  1996-06-14
• Entrez gene record
  4175
• RefSeq identity
  • NM_005915
• Classification
  • minichromosome maintenance 2-7 complex
  • MCM family
• VEGA ID
  OTTHUMG00000131739

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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