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Alternative_name
4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid; LA1
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Description
A novel small molecule agonist of integrin CD11b/CD18 (also known as Mac-1). LA1 increases the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils, which results in decreased chemotaxis and transendothelial migration. LA1 also decreases leukocyte recruitment and reduced arterial narrowing after injury in rats. In addition, compared to a known integrin antagonist IMB-10, LA1 better preserves kidney function in a mouse model of experimental nephritis.
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CAS Number
344897-95-6
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Structure Available
Yes
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Molecular Formula
C₂₂H₁₅NO₄S₂
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Molecular Weight
421.49
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Cell Permeable
Yes
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Purity
≥97% by HPLC
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Solubilities
DMSO (10 mM)
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Handling
Protect from air and light
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Tag Line
A small molecule agonist of integrin CD11b/CD18
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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PubChem CID
5342077
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SMILES
C1=CC=C(C=C1)CN2C(=O)C(=CC3=CC=C(O3)C4=CC=C(C=C4)C(=O)O)SC2=S
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InChi
InChI=1S/C22H15NO4S2/c24-20-19(29-22(28)23(20)13-14-4-2-1-3-5-14)12-17-10-11-18(27-17)15-6-8-16(9-7-15)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
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InChi Key
AEZGRQSLKVNPCI-UNOMPAQXSA-N
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MSDS Available
Yes
