R162

• Catalog number
  B1180-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  1-Hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione
• Description
  R162 is a cell-permeable, nontoxic selective inhibitor of Glutamate Dehydrogenase 1 (GDH1), (Ki = 28.6 µM) which is an upregulated enzyme in human cancers. It shows selectivity over other NADPH-dependent enzymes such as 6-phosphogluconate dehydrogenase (6PGD) and Fumarate hydratase (FH). It showes reduced levels of intracellular fumarate levels and Glutathione peroxidase (GPx) activity with increase in mitochondrial ROS levels. Decreases the tumor growth and inhibits the cancer cell proliferation of H1299 and primary leukemia cells.
• CAS Number
  64302-87-0
• Structure Available
  Yes
• Molecular Formula
  C₁₇H₁₂O₃
• Molecular Weight
  264.28
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (>10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A Glutamate Dehydrogenase 1 (GDH1) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• SMILES
  O=C1C2=C(C=CC=C2)C(C3=CC=C(CC=C)C(O)=C13)=O
• InChi
  InChI=1S/C17H12O3/c1-2-5-10-8-9-13-14(15(10)18)17(20)12-7-4-3-6-11(12)16(13)19/h2-4,6-9,18H,1,5H2
• InChi Key
  IMUBGIOLZQTIGI-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  R162  
• Short name
  R162
• Alternative name
  R162

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