anti- PTRH2 antibody
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Catalog numberFNab06951
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PricePlease ask
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Size2X100μg
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Formliquid
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PurificationImmunogen affinity purified
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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BackgroundThe protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms.
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Immunogenpeptidyl-tRNA hydrolase 2
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SynonymsBIT1, PTH2
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Calculated MW20 kDa
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Uniprot IDQ9Y3E5
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SpecificityHuman, Mouse, Rat
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Tested ApplicationELISA, WB, IHC, IF
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Recommended dilutionWB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100
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Image1Immunohistochemistry of paraffin-embedded human prostate cancer using FNab06951(PTRH2 antibody) at dilution of 1:10
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Image4HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab06951(PTRH2 antibody) at dilution of 1:1000
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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PropertiesIf you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolPTRH2
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Short nameanti- PTRH2 antibody
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TechniqueAntibody, anti, antibody to, antibodies against human proteins, antibodies for
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HostRabbit
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IsotypeIgG
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Alternative nameantibody to- peptidyl-tRNA hydrolase 2 (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetpeptidyl-tRNA hydrolase 2, PTRH2 and IDBG-61806 and ENSG00000141378 and 51651, protein binding, Plasma membranes, Ptrh2 and IDBG-206996 and ENSMUSG00000072582 and 217057, PTRH2 and IDBG-629776 and ENSBTAG00000016710 and 516595
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Gene info
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Identity
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Gene
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Long gene namepeptidyl-tRNA hydrolase 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2006-02-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Cilia and flagella associated
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
