Human CellExp™ LAG-3 / CD223, Cynomolgus Recombinant

• Catalog number
  P1179-10
• Price
  Please ask
• Size
  10 ug

• Synonyms
  LAG3, CD223, FDC
• Alternative_names
  LAG3, CD223, FDC
• Description
  A protein involved in lymphocyte activation
• Recombinant
  Yes
• Source
  HEK293 cells
• Purity by SDS PAGE
  > 85%
• Assay
  SDS-PAGE
• Endotoxin Level
  < 1.0 EU per/ug
• Activity Specifications test method
  Measured by its binding ability in a functional ELISA.
• Biological activity
  Immobilized Cynomolgus LAG-3, mouse IgG2a Fc tag at 2 ug/mL (100 ul/well) can bind Anti-LAG3 MAb,Human IgG1 with a linear range of 3-20 ng/ml.
• Binding Capacity
  Immobilized Cynomolgus LAG-3, mouse IgG2a Fc tag at 2 ug/mL (100 ul/well) can bind Anti-LAG3 MAb,Human IgG1 with a linear range of 3-20 ng/ml.
• Molecular Weight
  73.7 kDa
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized from 0.22 um filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.
• Reconstitution Instructions
  Reconstitute in sterile deionized water to the desired protein concentration.
• Background Information
  Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   LAG-3   CD223   Cynomolgus  
• Gene symbol
  LAG3, GNLY, MIR1302-3, MIR509-3, MIR7-3, PIRC14, PIRC12, MIR9-3
• Short name
  CellExp™ LAG-3 / CD223, Cynomolgus Recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ LAG-3 / CD223, Cynomolgus Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:6476
• Gene
  LAG3
• Long gene name
  lymphocyte activating 3
• Synonyms gene name
  • lymphocyte-activation gene 3
• Synonyms
  • CD223
• Locus
  12p13.31
• Discovery year
  1991-06-03
• Entrez gene record
  3902
• RefSeq identity
  • NM_002286
• Classification
  • Immunoglobulin like domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000169197

Gene info

• Identity
  HGNC:4414
• Gene
  GNLY
• Long gene name
  granulysin
• Synonyms gene
  • LAG2
• Synonyms
  • NKG5
  • LAG-2
  • D2S69E
  • TLA519
• Synonyms name
  • T-lymphocyte activation gene 519
• GenBank acession
  • X54101
• Locus
  2p11.2
• Discovery year
  1999-11-22
• Entrez gene record
  10578
• Pubmed identfication
  • 2212946
  • 2434598
• RefSeq identity
  • NM_006433
• VEGA ID
  OTTHUMG00000130179

Gene info

• Identity
  HGNC:35295
• Gene
  MIR1302-3
• Long gene name
  microRNA 1302-3
• Synonyms gene
  • MIRN1302-3
• Synonyms
  • hsa-mir-1302-3
• Locus
  2q14.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302128
• RefSeq identity
  • NR_031632
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:33675
• Gene
  MIR509-3
• Long gene name
  microRNA 509-3
• Synonyms gene
  • MIRN509-3
• Synonyms
  • hsa-mir-509-3
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126337
• RefSeq identity
  • NR_030629
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:31640
• Gene
  MIR7-3
• Long gene name
  microRNA 7-3
• Synonyms gene
  • MIRN7-3
• Synonyms
  • hsa-mir-7-3
• Locus
  19p13.3
• Discovery year
  2004-04-23
• Entrez gene record
  407045
• RefSeq identity
  • NR_029607
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:37518
• Gene
  PIRC14
• Long gene name
  piwi-interacting RNA cluster 14
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313784
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37516
• Gene
  PIRC12
• Long gene name
  piwi-interacting RNA cluster 12
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313808
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:31646
• Gene
  MIR9-3
• Long gene name
  microRNA 9-3
• Synonyms gene
  • MIRN9-3
• Synonyms
  • hsa-mir-9-3
• Locus
  15q26.1
• Discovery year
  2004-04-23
• Entrez gene record
  407051
• RefSeq identity
  • NR_029692
• Classification
  • MicroRNA MIR9 family

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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