PX-478 hydrochloride

• Catalog number
  B1033-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (S)-4-(2-amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride
• Description
  PX-478 hydrochloride is an inhibitor of HIF-1α (IC₅₀ of 20-30 μM) with potential antineoplastic activity. PX-478 inhibits HIF-1alpha protein levels and transactivation in a variety of cancer cell lines. The inhibitory effect of PX-478 on HIF-1alpha levels is primarily due to its inhibition of translation because HIF-1alpha translation continues in hypoxia when translation of most proteins is decreased.
• CAS Number
  685898-44-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₃H₂₀Cl₄N₂O
• Molecular Weight
  394.11
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  H₂O (> 5 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A HIF-1α inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  11234794
• PubChem CID Link
• SMILES
  C1=CC(=CC=C1CC(C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl
• InChi
  InChI=1S/C13H18Cl2N2O3.2ClH/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;;/h1-4,12H,5-9,16H2,(H,18,19);2*1H/t12-;;/m0../s1
• InChi Key
  GIGCDIVNDFQKRA-LTCKWSDVSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  PX-478   hydrochloride  
• Short name
  PX-478 hydrochloride
• Alternative name
  PX-478 hydrochloride

Product images

Similar products