RABBIT ANTI ORAI3 (N-TERMINAL)

• Catalog number
  MBS222947
• Price
  Please ask
• Size
  0.1 mg

• Products_type
  Antibody
• Products_short_name
  [ORAI3]
• Other_names
  [protein orai-3; Protein orai-3; protein orai-3; transmembrane protein 142C; ORAI calcium release-activated calcium modulator 3; Transmembrane protein 142C]
• Products_gene_name
  [ORAI3]
• Other_gene_names
  [ORAI3; ORAI3; TMEM142C; TMEM142C]
• Clonality
  Polyclonal
• Reactivity
  Mouse, Rat
• Specificity
  This item recognises human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kDa multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. This item is not expected to cross react with either ORAI1 or ORAI2.
• Form
  Purified Purified IgG - liquid
• Concentration
  IgG concentration 1.0mg/ml
• Storage_stability
  Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
• Tested_application
  Immunohistology Frozen, Western Blot (WB)
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• About
  Rabbits are used for polyclonal antibody production by MyBioSource. Rabbit antibodies are very stable and can be stored for several days at room temperature. MyBioSource adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus

• Gene target
  ORAI3  
• Gene symbol
  ORAI3
• Short name
  RABBIT ANTI ORAI3 (N-TERMINAL)
• Technique
  Rabbit, anti, antibody to
• Host
  Rabbit, Rabbits
• Isotype
  IgG
• Alternative name
  production species: rabbit antibody to ORAI3 (N-TERMINAL)
• Alternative technique
  rabbit-anti, antibodies

Gene info

• Identity
  HGNC:28185
• Gene
  ORAI3
• Long gene name
  ORAI calcium release-activated calcium modulator 3
• Synonyms gene
  • TMEM142C
• Synonyms gene name
  • transmembrane protein 142C
• Synonyms
  • MGC13024
• GenBank acession
  • BC006126
• Locus
  16p11.2
• Discovery year
  2006-06-20
• Entrez gene record
  93129
• Pubmed identfication
  • 16582901
  • 26956485
  • 26718630
  • 23890118
• RefSeq identity
  • NM_152288
• Classification
  • ORAI calcium release-activated calcium modulators
• VEGA ID
  OTTHUMG00000176768

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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