L-DON

• Catalog number
  B1955-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  H-Glu(diazomethylketone)-OH, 6-Diazo-5-oxo-L-2-aminohexanoic acid; 6-Diazo-5-oxo-L-norleucine
• Description
  L-DON is a glutamine antagonist produced naturally by Streptomyces; it inhibits several glutamine-dependent enzyme pathways as well as acts as an inhibitor of the mitochondrial enzyme, glutaminase (GLS), the primary producer of neuronal glutamate.
• CAS Number
  157-03-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₆H₉N₃O₃
• Molecular Weight
  171.16
• Cell Permeable
  Yes
• Purity
  ≥95% by TLC
• Solubilities
  PBS (pH 7.2, 10 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A glutamine antagonist
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00037218
• PubChem CID
  5359375
• PubChem CID Link
• SMILES
  C(CC(=C[N+]#N)[O-])C(C(=O)O)N
• InChi
  InChI=1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H-,10,11,12)/b4-3-/t5-/m0/s1
• InChi Key
  MKZFABOMIIHLIT-XUELKZDXSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  L-DON  
• Gene symbol
  NRG2, CPT1A, POM121L2, L3MBTL2, CLDN10, RPL32P1, FABP1, COX7A2, NFIA, MAS1L
• Short name
  L-DON
• Alternative name
  L-DON

Gene info

• Identity
  HGNC:7998
• Gene
  NRG2
• Long gene name
  neuregulin 2
• Synonyms
  • Don-1
  • NTAK
  • HRG2
• Synonyms name
  • neural- and thymus-derived activator for ErbB kinases
  • divergent of neuregulin-1
• Locus
  5q31.2
• Discovery year
  1999-03-19
• Entrez gene record
  9542
• Pubmed identfication
  • 9168114
  • 9168115
• RefSeq identity
  • NM_013982
• Classification
  • Neuregulins
  • I-set domain containing
• VEGA ID
  OTTHUMG00000129241

Gene info

• Identity
  HGNC:2328
• Gene
  CPT1A
• Long gene name
  carnitine palmitoyltransferase 1A
• Synonyms gene
  • CPT1
• Synonyms gene name
  • carnitine palmitoyltransferase 1A (liver)
• Synonyms
  • CPT1-L
  • L-CPT1
• GenBank acession
  • L39211
• Locus
  11q13.3
• Discovery year
  1995-05-30
• Entrez gene record
  1374
• Pubmed identfication
  • 7892212
  • 9070950
• RefSeq identity
  • NM_001876
• VEGA ID
  OTTHUMG00000167892

Gene info

• Identity
  HGNC:13973
• Gene
  POM121L2
• Long gene name
  POM121 transmembrane nucleoporin like 2
• Synonyms gene name
  • POM121 membrane glycoprotein-like 2 (rat)
  • POM121 membrane glycoprotein-like 2
  • POM121 transmembrane nucleoporin-like 2
• Synonyms
  • POM121-L
• GenBank acession
  • AL021808
• Locus
  6p22.1
• Discovery year
  2001-07-20
• Entrez gene record
  94026
• RefSeq identity
  • NM_033482
• VEGA ID
  OTTHUMG00000014475

Gene info

• Identity
  HGNC:18594
• Gene
  L3MBTL2
• Long gene name
  L3MBTL histone methyl-lysine binding protein 2
• Synonyms gene name
  • l(3)mbt-like 2 (Drosophila)
  • L3MBTL2, polycomb repressive complex 1 subunit
• Synonyms
  • H-l(3)mbt-l
  • DKFZP761I141
  • dJ756G23.3
• GenBank acession
  • AJ305226
• Locus
  22q13.2
• Discovery year
  2002-04-29
• Entrez gene record
  83746
• Pubmed identfication
  • 11682070
  • 21596310
• RefSeq identity
  • NM_031488
• Classification
  • MBT domain containing
• VEGA ID
  OTTHUMG00000150942

Gene info

• Identity
  HGNC:2033
• Gene
  CLDN10
• Long gene name
  claudin 10
• Synonyms
  • OSP-L
  • CPETRL3
• GenBank acession
  • U89916
• Locus
  13q32.1
• Discovery year
  1999-01-22
• Entrez gene record
  9071
• Pubmed identfication
  • 18025272
• RefSeq identity
  • NM_006984
• Classification
  • Claudins
• VEGA ID
  OTTHUMG00000017217

Gene info

• Identity
  HGNC:10339
• Gene
  RPL32P1
• Long gene name
  ribosomal protein L32 pseudogene 1
• Synonyms gene
  • RPL32P
• Synonyms gene name
  • ribosomal protein L32 pseudogene
• Synonyms
  • RPL32-L
• GenBank acession
  • X02228
• Locus
  6p21.32
• Discovery year
  2009-03-01
• Entrez gene record
  6163
• Pubmed identfication
  • 3866218
  • 19123937
• RefSeq identity
  • NG_000869
• VEGA ID
  OTTHUMG00000031191

Gene info

• Identity
  HGNC:3555
• Gene
  FABP1
• Long gene name
  fatty acid binding protein 1
• Synonyms gene name
  • fatty acid binding protein 1, liver
• Synonyms
  • L-FABP
• GenBank acession
  • M10617
• Locus
  2p11.2
• Discovery year
  2001-06-22
• Entrez gene record
  2168
• Pubmed identfication
  • 3012800
  • 17698986
• RefSeq identity
  • NM_001443
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000130312

Gene info

• Identity
  HGNC:2288
• Gene
  COX7A2
• Long gene name
  cytochrome c oxidase subunit 7A2
• Synonyms gene name
  • cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
• Synonyms
  • COXVIIa-L
  • COX7AL
• GenBank acession
  • X15822
• Locus
  6q14.1
• Discovery year
  1992-11-25
• Entrez gene record
  1347
• Pubmed identfication
  • 1327965
  • 9202412
• RefSeq identity
  • NM_001865
• Classification
  • Mitochondrial complex IV: cytochrome c oxidase subunits
• VEGA ID
  OTTHUMG00000015049

Gene info

• Identity
  HGNC:7784
• Gene
  NFIA
• Long gene name
  nuclear factor I A
• Synonyms gene name
  • nuclear factor I/A
• Synonyms
  • NFI-L
  • KIAA1439
• GenBank acession
  • U07809
• Locus
  1p31.3
• Discovery year
  1995-03-09
• Entrez gene record
  4774
• Pubmed identfication
  • 7590749
• RefSeq identity
  • NM_005595
• Classification
  • Nuclear factor I family
• VEGA ID
  OTTHUMG00000008618

Gene info

• Identity
  HGNC:13961
• Gene
  MAS1L
• Long gene name
  MAS1 proto-oncogene like, G protein-coupled receptor
• Synonyms gene name
  • MAS1 oncogene-like
• Synonyms
  • MAS-L
  • MRG
  • dJ994E9.2
• GenBank acession
  • S78653
• Locus
  6p22.1
• Discovery year
  2002-11-18
• Entrez gene record
  116511
• RefSeq identity
  • NM_052967
• Classification
  • G protein-coupled receptors, Class A orphans
• VEGA ID
  OTTHUMG00000031089

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