GSK-2118436 mesylate
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Catalog number2800-25
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PricePlease ask
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Size25 mg
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Alternative_nameN-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide, methanesulfonic acid; Dabrafenib Mesylate
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DescriptionGSK2118436 is a selective BRAF V600E inhibitor. GSK2118436 binds to Raf family kinases and inhibits their activity. It is highly selective against B-Raf V600E with IC₅₀ of 0.8 nM, compared to wild type B-Raf and c-Raf with IC₅₀s of 3.2 nM and 5.0 nM, respectively.
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CAS Number1195768-06-9
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Structure AvailableY
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Salt FormNo
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Molecular FormulaC₂₄H₂₄F₃N₅O₅S₃
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Molecular Weight615.67
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Cell PermeableY
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Purity≥98% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and moisture
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Tag LineA selective BRAF V600E inhibitor
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Storage Condition-20°C
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Shipping ConditionGel Pack
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Shelf Life36 months
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PubChem CID44516822
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SMILESO=S(C1=C(F)C=CC=C1F)(NC2=CC=CC(C3=C(C4=NC(N)=NC=C4)SC(C(C)(C)C)=N3)=C2F)=O.CS(O)(=O)=O
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InChiInChI=1S/C23H20F3N5O2S2.CH4O3S/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25;1-5(2,3)4/h4-11,31H,1-3H3,(H2,27,28,29);1H3,(H,2,3,4)
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InChi KeyYKGMKSIHIVVYKY-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameGSK-2118436 mesylate
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Alternative nameGSK-2118436 mesylate
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