IACS-010759

• Catalog number
  B2231-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole
• Description
  IACS-010759 is a potent and selective Oxidative Phosphorylation Inhibitor (IC₅₀ < 10 nM) with potential antineoplastic activity. IACS-010759 robustly inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis.
• CAS Number
  1570496-34-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₅H₂₅F₃N₆O₄S
• Molecular Weight
  562.57
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent and selective Oxidative Phosphorylation Inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  86711931
• PubChem CID Link
• SMILES
  CC1=NC(=NN1CC2=CC(=CC=C2)N3CCC(CC3)S(=O)(=O)C)C4=NC(=NO4)C5=CC=C(C=C5)OC(F)(F)F
• InChi
  InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28)31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14,21H,10-13,15H2,1-2H3
• InChi Key
  HWJWNWZJUYCGKV-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  IACS-010759  
• Short name
  IACS-010759
• Alternative name
  IACS-010759

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