Apoptosis inhibitor

• Catalog number
  2783-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione
• Description
  Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction. It does not directly inhibit caspase-3, but effects are attributable to the inhibition of caspase-3 activation.
• CAS Number
  54135-60-3
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₁₃H₁₆O₄
• Molecular Weight
  236.3
• Cell Permeable
  Y
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO or EtOH
• Handling
  Protect from air and light
• Tag Line
  An apoptosis inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  2748618
• PubChem CID Link
• SMILES
  C1CC(=O)C(C(=O)C1)CC2C(=O)CCCC2=O
• InChi
  InChI=1S/C13H16O4/c14-10-3-1-4-11(15)8(10)7-9-12(16)5-2-6-13(9)17/h8-9H,1-7H2
• InChi Key
  ILUMEPMGPCKGHH-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  This 1 is suited for programmed cell-death studies. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  inhibitor  
• Gene symbol
  PI15, TFPI, SPINK2
• Short name
  Apoptosis inhibitor
• Technique
  apoptosis, apoptosis pathway
• Alternative name
  programmed cellular destruction suppressor
• Alternative technique
  celldeath

Gene info

• Identity
  HGNC:8946
• Gene
  PI15
• Long gene name
  peptidase inhibitor 15
• Synonyms gene name
  • protease inhibitor 15
• Synonyms
  • P25TI
• GenBank acession
  • D45027
• Locus
  8q21.13
• Discovery year
  2000-08-11
• Entrez gene record
  51050
• Pubmed identfication
  • 8882727
  • 9473672
• RefSeq identity
  • NM_015886
• Classification
  • CAP superfamily
• VEGA ID
  OTTHUMG00000164528

Gene info

• Identity
  HGNC:11760
• Gene
  TFPI
• Long gene name
  tissue factor pathway inhibitor
• Synonyms gene
  • LACI
• Synonyms gene name
  • tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
• Synonyms
  • EPI
  • TFI
  • TFPI1
• Synonyms name
  • extrinsic pathway inhibitor
• Locus
  2q32.1
• Discovery year
  1991-06-03
• Entrez gene record
  7035
• Pubmed identfication
  • 1993173
• RefSeq identity
  • NM_006287
• VEGA ID
  OTTHUMG00000132634
• Locus Specific Databases
  • LRG_604

Gene info

• Identity
  HGNC:11245
• Gene
  SPINK2
• Long gene name
  serine peptidase inhibitor Kazal type 2
• Synonyms gene name
  • serine protease inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
• Synonyms
  • HUSI-II
• Synonyms name
  • acrosin-trypsin inhibitor
• GenBank acession
  • BC022514
• Locus
  4q12
• Discovery year
  1993-12-01
• Entrez gene record
  6691
• Pubmed identfication
  • 8428671
• RefSeq identity
  • NM_021114
• Classification
  • Serine peptidase inhibitors, Kazal type
• VEGA ID
  OTTHUMG00000128769

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