Anti-EYA3 Antibody

• Catalog number
  A1629-100
• Price
  Please ask
• Size
  100 µl

• Antibody Target
  EYA3
• Target Alternative Name
  Eyes absent homolog 3
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, Mouse, Rat
• Immunogen Sequence
  Recombinant full length protein of human EYA3
• Accession
  Q99504
• Gene Id
  2140
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  1 mg/ml
• Formulation
  In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
• Purification
  Affinity purified
• Application
  WB, IHC
• Positive Control
  WB: Hela; HT29; mouse eye; mouse testis; rat brain; rat liver whole cell lysates, IHC: rat kidney
• Application And Usages
  WB; 1:500 – 1:2000, IHC; 1:50 – 1:200
• Description
  Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity. May be involved in development of the eye.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  EYA3  
• Gene symbol
  EYA3
• Short name
  Anti-EYA3 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibody toEYA3 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3521
• Gene
  EYA3
• Long gene name
  EYA transcriptional coactivator and phosphatase 3
• Synonyms gene name
  • eyes absent (Drosophila) homolog 3
  • eyes absent homolog 3 (Drosophila)
• Synonyms
  • DKFZp686C132
• GenBank acession
  • U81602
• Locus
  1p35.3
• Discovery year
  1997-06-24
• Entrez gene record
  2140
• Pubmed identfication
  • 9020840
• RefSeq identity
  • NM_001990
• Classification
  • EYA transcriptional coactivator and phosphatases
• VEGA ID
  OTTHUMG00000003916

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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