Recombinant Mouse Apoptosis-mediating Surface Antigen FAS Protein
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Catalog numberPKSM040905-10µg
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PricePlease ask
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Size10µg
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SynonymTumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD95;Fas;TNFRSF6
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ActivityMeasured by its ability to inhibit Fas Ligand induced apoptosis of Jurkat human acute T cell leukemia cells.The ED50 for this effect is typically 1-8 μg/mL in the presence of 20 ng/mL recombinant human Fas ligand.
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SequenceMet 1-Arg 169
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Fusion tagC-6His
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AccessionNP_032013.2
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Expressed HostHuman Cells
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ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity>95% as determined by reducing SDS-PAGE.
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Stability and StorageLyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
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Mol Mass17.4 kDa
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AP Mol Mass25-35 kDa
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FormulationLyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
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BackgroundMouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
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DescriptionAntigens are peptides or recombinant or native dependent on the production method. This 1 is suited for programmed cell-death studies.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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SourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolFAS-AS1, FASN, FAS
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Short nameRecombinant Mouse Apoptosis-mediating Surface Antigen FAS Protein
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TechniqueRecombinant, apoptosis, antigen, Mouse, antigenes, apoptosis pathway, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Hostmouse
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SpeciesMouse, Mouses
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Alternative nameRec. Mouse programmed cellular destruction-mediating Surface protein Fas (tumor necrosis factor receptor superfamily, member 6) Protein
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Alternative techniquerec, celldeath, antigenes, murine
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Alternative to gene targetFas (TNF receptor superfamily, member 6), ALPS1A and APO-1 and APT1 and CD95 and FAS1 and FASTM and TNFRSF6, FAS and IDBG-81669 and ENSG00000026103 and 355, identical protein binding, nuclei, Fas and IDBG-159577 and ENSMUSG00000024778 and 14102, FAS and IDBG-637356 and ENSBTAG00000010785 and 282488
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Gene info
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Identity
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Gene
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Long gene nameFAS antisense RNA 1
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Synonyms gene
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Synonyms gene name
- FAS antisense RNA (non-protein coding)
- FAS antisense RNA 1 (non-protein coding)
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Synonyms
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Locus
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Discovery year2009-07-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
Gene info
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Identity
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Gene
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Long gene namefatty acid synthase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1994-05-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Short chain dehydrogenase/reductase superfamily
- 7BS orphan methyltransferases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameFas cell surface death receptor
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor receptor superfamily, member 6
- Fas (TNF receptor superfamily, member 6)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-06-25
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Entrez gene record
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Pubmed identfication
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Classification
- Tumor necrosis factor receptor superfamily
- Death inducing signaling complex
- CD molecules
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data