Caspase-8 Antibody

• Catalog number
  3020-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  Caspase-8
• Target Alternative Name
  CASP8 , mgC78473 , CASP-8, MACH, procaspase-8, MCH5, ALPS2B, FLICE, CAP4, EC 3.4.22.61
• Antibody Type
  Polyclonal
• Species Reactivities
  mouse, rat, bovine, monkey
• Immunogen Sequence
  Synthetic peptide surrounding amino acid 392 of mouse caspase-8
• Accession
  BC006737
• Gene Id
  12370
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.5 mg/ml
• Formulation
  In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin.
• Purification
  Affinity purified
• Application
  Western blot
• Application And Usages
  Western blotting (0.5-4 µg/ml). The immunoaffinity purified antibody detects the full length (55 kDa), intermediate cleavage fragments (26-31 kDa) and cleaved large fragment (18 kDa) of caspase-8.
• Description
  Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-8 is a 55 kDa cytosolic protein that is synthesized as an inactive pro-enzyme. Activation of caspase-8 involves a two-step proteolysis: the cleavage of caspase-8 to generate a 43 and a 12 kDa fragment which is further processed to 10 kDa. The p43 is then cleaved to yield p26 and the release of the active site containing p18.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Additional description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
• French translation
  anticorps

• Gene target
  Caspase-8  
• Gene symbol
  CASP8, CARD8, CASP8AP2
• Short name
  Caspase-8 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  caspase-8 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1509
• Gene
  CASP8
• Long gene name
  caspase 8
• Synonyms gene name
  • caspase 8, apoptosis-related cysteine protease
  • caspase 8, apoptosis-related cysteine peptidase
• Synonyms
  • MCH5
  • MACH
  • FLICE
  • Casp-8
• GenBank acession
  • U60520
• Locus
  2q33.1
• Discovery year
  1996-11-11
• Entrez gene record
  841
• Pubmed identfication
  • 8681376
  • 8681377
• RefSeq identity
  • NM_001228
• Classification
  • Caspases
  • Death effector domain containing
  • Death inducing signaling complex
  • Ripoptosome
• VEGA ID
  OTTHUMG00000132821
• Locus Specific Databases
  • CASP8base: Mutation registry for Caspase 8 deficiency
  • LRG_34

Gene info

• Identity
  HGNC:17057
• Gene
  CARD8
• Long gene name
  caspase recruitment domain family member 8
• Synonyms gene name
  • caspase recruitment domain family, member 8
• Synonyms
  • TUCAN
  • KIAA0955
  • CARDINAL
  • NDPP
  • Dakar
• GenBank acession
  • AB023172
• Locus
  19q13.33
• Discovery year
  2003-12-03
• Entrez gene record
  22900
• Pubmed identfication
  • 10231032
  • 11408476
• RefSeq identity
  • NM_014959
• Classification
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000165047

Gene info

• Identity
  HGNC:1510
• Gene
  CASP8AP2
• Long gene name
  caspase 8 associated protein 2
• Synonyms gene name
  • CASP8 associated protein 2
• Synonyms
  • FLASH
  • CED-4
  • RIP25
  • FLJ11208
  • KIAA1315
• Synonyms name
  • FLICE-associated huge protein
• GenBank acession
  • AB037736
• Locus
  6q15
• Discovery year
  1999-12-10
• Entrez gene record
  9994
• Pubmed identfication
  • 10235259
  • 17245429
  • 17003126
• RefSeq identity
  • NM_001137667
• VEGA ID
  OTTHUMG00000015212

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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