NECA
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Catalog numberB2262-25
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PricePlease ask
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Size25 mg
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Alternative_name1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide; 5'-N-Ethylcarboxamidoadenosine
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DescriptionNECA is a high affinity adenosine receptor agonist (Ki values are 6.2, 14, and 20 nM for human A3, A1 and A2A receptors respectively; EC₅₀ = 2.4 μM for human A2B). NECA is also reported to act as a potent vasodilator and can inhibit platelet aggregation by increasing cAMP (EC₅₀ = 3.1 µM).
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CAS Number35920-39-9
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₂H₁₆N₆O₄
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Molecular Weight308.3
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>10 mg/ml)
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HandlingProtect from air and light
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Tag LineA high affinity adenosine receptor agonist
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD00069195
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PubChem CID448222
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SMILESCCNC(=O)C1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O
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InChiInChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
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InChi KeyJADDQZYHOWSFJD-FLNNQWSLSA-N
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MSDS AvailableYES
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Gene target
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Short nameNECA
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Alternative nameNECA
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